Research from University of Utah, Medical Department has provided new information about immunology
2007 NOV 21 -- "Despite the unequivocal role of B lymphocytes as effecter cells in humoral immunity, studies have reported that B cells are tolerogenic. The impact of B cell-mediated tolerance and its underlying mechanisms are incompletely understood," researchers in the United States report. "Using primary B cells as APCs and allogeneic CD4 T cells as responder cells in mixed leukocyte reactions, we find that B cells preferentially expand ToxP3(+) over FoxP3(-) CD4 T cells in the absence of exogenous cytokines. The preferential expansion of Foxp3(+) T cells is further enhanced by a partial blockade of class H MHC- TCR interaction but diminished by stimulatory anti-CD28 Ab or at high B to T cell ratios. Gamma irradiation of B cells selectively abrogates their ability to expand isolated CD25(+) but not CD25(-) CD4 T cells, exogenous IL-2 supplement can partially restore this function," wrote X.J. Chen and colleagues, University of Utah, Medical Department. The researchers concluded: "B cell-expanded CD25+ T cells express high levels of FoxP3 and are highly inbibitoryin an Ag-specific manner." Chen and colleagues published their study in the Journal of Immunology (Cutting edge: Primary B lmphocytes preferentially expand allogeneic FoxP3(+) CD4 T cells. Journal of Immunology, 2007;179(4):2046-2050). For additional information, contact X.J. Chen, University of Utah, School Medical, Dept. of Pathology, 1520 Emma Eccles Jones Bldg, 30 N 1900 E, Salt Lake City, UT 84132, USA. Publisher contact information for the Journal of Immunology is: American Association Immunologists, 9650 Rockville Pike, Bethesda, MD 20814, USA. Keywords: United States, Salt Lake City, Immunology, University of Utah, Medical Department. This article was prepared by Immunotherapy Weekly editors from staff and other reports. Copyright 2007, Immunotherapy Weekly via NewsRx.com.
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