Research from Tokai University in the area of flu vaccines published
2007 NOV 5 -- Scientists discuss in 'Long- and short-time immunological memory in different strains of mice given nasally an adjuvant-combined nasal influenza vaccine' new findings in flu. "Immunological memory induced by nasal immunization with adjuvant-combined influenza vaccine was analyzed in different ages and strains of mice. The memory activities were assessed by secondary nasal-wash IgA and serum IgG antibody (Ab) responses and protection against challenge infection with a lethal dose of influenza virus," scientists in Kanagawa, Japan report. "Mice were primed with 0.1 microg of vaccine and boosted with 0.1 or 1.0 microg vaccine 1 (short-term memory)-or 17 (long-term memory)-months later. Influenza-specific short-term memory responses in young adult BALB/c mice (2-month-old) were significantly higher than those of long-term memory activities in mice boosted at 19 months of age. However, those influenza-specific long-term memory responses provided protective immunity against influenza virus challenge and were higher than short-term memory in aged mice primed at 18-month-old and boosted 1 month later. These results show that the age at which initial nasal immunization is given is critically important in order to induce protective immunity in aged mice. Similar findings were noted in the C3H mouse strain; however, C57BL/6 mice failed to induce influenza-specific immune responses in both young adult and aged mice," wrote H. Asanuma and colleagues, Tokai University. The researchers concluded: "These results indicate that low doses of cholera toxin B subunit (supplemented with 0.2% of hole toxin) combined nasal vaccine may required further improvement in order to provide protective immunity in human use." Asanuma and colleagues published their study in Vaccine (Long- and short-time immunological memory in different strains of mice given nasally an adjuvant-combined nasal influenza vaccine. Vaccine, 2007;25(39-40):6975-80). For more information, contact H. Asanuma, School or Engineering, Dept. of Applied Biochemistry, Tokai University, Kitakaname 1117, Hiratsuka-shi, Kanagawa 259-1292, Japan. Publisher contact information for the journal Vaccine is: Elsevier Science Ltd., the Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. Keywords: Japan, Kanagawa, Biotechnology, Flu Vaccines, Immunization, Influenza Vaccines, Vaccination. This article was prepared by Pharma Business Week editors from staff and other reports. Copyright 2007, Pharma Business Week via NewsRx.com.
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