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Research from D. Fenoglio and co-researchers yields new findings on HIV/AIDS
2009 AUG 24 - (NewsRx.com) -- According to recent research published in the journal Blood, "In early HIV-1 infection, V delta 1 T lymphocytes are increased in peripheral blood and this is related to chemokine receptor expression, chemokine response, and recirculation. Herein we show that, at variance with healthy donors, in HIV-1-infected patients ex vivo-isolated V delta 1 T cells display cytoplasmic interferon-gamma (IFN-gamma)." "Interestingly, these cells coexpress cytoplasmic interleukin-17 (IL-17), and bear the CD27 surface marker of the memory T-cell subset. V delta 1 T cells, isolated from either patients or healthy donors, can proliferate and produce IFN-gamma and IL-17 in response to Candida albicans in vitro, whereas V delta 2 T cells respond with proliferation and IFN-gamma/IL-17 production to mycobacterial or phosphate antigens. These IFN-gamma/IL-17 double-producer gamma delta T cells express the Th17 RORC and the Th1 TXB21 transcription factors and bear the CCR7 homing receptor and the CD161 molecule that are involved in gamma delta T-cell transendothelial migration. Moreover, V delta 1 T cells responding to C albicans express the chemokine receptors CCR4 and CCR6," wrote D. Fenoglio and colleagues. The researchers concluded: "This specifically equipped circulating memory gamma delta T-cell population might play an important role in the control of HIV-1 spreading and in the defense against opportunistic infections, possibly contributing to compensate for the impairment of CD4(+) T cells. (Blood. 2009; 113:6611-6618)." Fenoglio and colleagues published their study in Blood (V delta 1 T lymphocytes producing IFN-gamma and IL-17 are expanded in HIV-1-infected patients and respond to Candida albicans. Blood, 2009;113(26):6611-6618). For additional information, contact A. Poggi, National Institute Cancer Research, Immunology Laboratory, Largo R Benzi 10, I-16132 Genoa, Italy. The publisher's contact information for the journal Blood is: American Society Hematology, 1900 M Street. NW Suite 200, Washington, DC 20036, USA. Keywords: Italy, Genoa, HIV/AIDS, AIDS, Acquired Immunodeficiency Syndrome, Circulation, HIV, Human Immunodeficiency Virus, Immunology, Interferon, Interferon Gamma, Virology. This article was prepared by AIDS Weekly editors from staff and other reports. Copyright 2009, AIDS Weekly via NewsRx.com.
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