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Research data from Kaohsiung Medical University, Department of Internal Medicine update understanding of kidney failure risk factors
2009 JUN 22 - (NewsRx.com) -- A report, 'Acute renal failure and its risk factors in Stevens-Johnson syndrome and toxic epidermal necrolysis,' is newly published data in American Journal of Nephrology. According to recent research from Kaohsiung, Taiwan, "Skin lesion is the most frequent manifestation of adverse drug reactions. Drug-induced cutaneous hypersensitivity and drug-induced acute interstitial nephritis might share a similar mechanism involving drug-specific T cells." "We thus investigated the renal outcome of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), the most severe drug-induced cutaneous hypersensitivity, and hypothesize that skin detachment in SJS/TEN might be associated with acute renal failure (ARF). 234 hospitalized patients were retrospectively classified into an SJS/TEN group (skin detachment) or an erythematous multiforme majus group (target-like exanthema alone). Both drugs and chronic kidney disease (CKD) are associated with SJS/TEN. The SJS/TEN group was more likely to develop ARF than the erythematous multiforme majus group (18.8 vs. 4.3%, p<0.05) despite similar initial creatinine clearance. In the ARF patients, RIFLE-F class, dialysis and long-term dialysis were 25, 15 and 5%, respectively. The offending drugs in ARF were also associated with CKD. Hyponatremia and late hypokalemia were more frequently in the SJS/TEN group (15.6 vs. 2.9%, 7.3 vs. 0.7%, respectively, p<0.05). Sepsis, allopurinol, antibiotics, NSAIDs, CKD and hypoalbuminemia (OR: 18.8, 9.8, 10.1, 9.0, 5.3 and 3.3, respectively, p<0.05) were the risk factors of developing ARF. ARF, the need for dialysis, and late hypokalemia could be the consequences of SJS/TEN," wrote C.C. Hung and colleagues, Kaohsiung Medical University, Department of Internal Medicine. The researchers concluded: "Skin detachment after certain medication might implicate the associated ARF, especially in CKD patients." Hung and colleagues published their study in American Journal of Nephrology (Acute renal failure and its risk factors in Stevens-Johnson syndrome and toxic epidermal necrolysis. American Journal of Nephrology, 2009;29(6):633-8). For additional information, contact C.C. Hung, Dept. of Internal Medicine, Division of Nephrology, Kaohsiung Medical University, Kaohsiung, Taiwan, Taiwan. Publisher contact information for the American Journal of Nephrology is: S. Karger AG, Allschwilerstrasse 10, CH-4009 Basel, Switzerland. Keywords: Taiwan, Kaohsiung, Kidney Failure Risk Factors, Acute Kidney Failure, Acute Renal Failure, Adverse Drug Effect, Adverse Drug Event, Adverse Drug Reaction, Dermatology, Drug Development, Exanthema, Hypersensitivity, Internal Medicine, Interstitial Nephritis, Kidney, Kidney Disease, Nephrology, Renal Failure, Stevens-Johnson Syndrome, Therapy, Toxic Epidermal Necrolysis, Treatment. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
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