The news correspondents obtained a quote from the research, "Cross-sectional study of a cohort of HIV outpatients in regular follow-up. Demographic, epidemiological, clinical, analytical and therapeutic data were collected. Patients completed a questionnaire about CVR factors and 10-year CV disease risk estimation (Framingham score), underwent a physical exam, and a fasting blood analysis. IO was defined as a plasma ferritin level higher than 200 /L in women and 300 /L in men. 571 patients (446 men, 125 women), with a mean age of 43.2 years, sexual transmission of HIV in 68.5%, median CD4 count 474 cell/L (IQR: 308-666), and 36.3% Aids cases. 86.2% were on antiretroviral therapy (ART), and 74.8% of them had undetectable HIV viral load. 14.6% met MS criteria, and mean CVR at 10 years was 6.67%. IO was detected in 11% of cases. Patients with IO were more immunosuppressed (CD4 count 369 vs 483/L, p<0.0001), presented a higher prevalence of detectable HIV viral load (17.6% vs 8.9%; p<0.005), and of Aids cases (14.9% vs 8.7%; p<0.023), and lower plasma levels of cholesterol, HDLc and LDLc (154 vs 183, 34 vs 43, 93 vs 110 mg/dL, respectively; p<0.0001. In the multivariate analysis, the only related factor was CD4 count <350 cell/L (OR 2.86, 95% CI 1.6-4.9; p<0.0001). IO was not associated with CVR nor with MS."
According to the news reporters, the research concluded: "IO is not uncommon in HIV patients, and it is only related with immunosuppression defined as CD4 count <350 cell/L, and in contrast to general population, it is not related with increased CVR nor with MS."
For more information on this research see: Iron overload, an immunosuppression marker in HIV-infected patients. Journal of the International Aids Society, 2012;15(6):18304. (BioMed Central - www.biomedcentral.com/; Journal of the International Aids Society - www.jiasociety.org)
Our news journalists report that additional information may be obtained by contacting C. Lopez-Calderon, Hospital Virgen de la Victoria, Malaga, Spain.
Keywords for this news article include: Spain, Malaga, Europe, HIV/AIDS, RNA Viruses, Retroviridae, Iron Overload, HIV Infections, AIDS/HIV Research, Immunosuppression, Metabolic Diseases, Vertebrate Viruses, Primate Lentiviruses, Iron Metabolism Disorders, Viral Sexually Transmitted Diseases.
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