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Studies from C. Lopez-Calderon and Colleagues Reveal New Findings on AIDS/HIV Research

2013 JAN 7 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Investigators publish new report on AIDS/HIV Research. According to news reporting from Malaga, Spain, by NewsRx journalists, research stated, "Iron overload (IO) has been associated with increased cardiovascular risk (CVR) and metabolic syndrome (MS) in the general population; both elevated CVR and MS are frequent in HIV-patients. Our aim was to analyze the prevalence of IO in a cohort of asymptomatic patients with HIV infection, and related factors."

The news correspondents obtained a quote from the research, "Cross-sectional study of a cohort of HIV outpatients in regular follow-up. Demographic, epidemiological, clinical, analytical and therapeutic data were collected. Patients completed a questionnaire about CVR factors and 10-year CV disease risk estimation (Framingham score), underwent a physical exam, and a fasting blood analysis. IO was defined as a plasma ferritin level higher than 200 /L in women and 300 /L in men. 571 patients (446 men, 125 women), with a mean age of 43.2 years, sexual transmission of HIV in 68.5%, median CD4 count 474 cell/L (IQR: 308-666), and 36.3% Aids cases. 86.2% were on antiretroviral therapy (ART), and 74.8% of them had undetectable HIV viral load. 14.6% met MS criteria, and mean CVR at 10 years was 6.67%. IO was detected in 11% of cases. Patients with IO were more immunosuppressed (CD4 count 369 vs 483/L, p<0.0001), presented a higher prevalence of detectable HIV viral load (17.6% vs 8.9%; p<0.005), and of Aids cases (14.9% vs 8.7%; p<0.023), and lower plasma levels of cholesterol, HDLc and LDLc (154 vs 183, 34 vs 43, 93 vs 110 mg/dL, respectively; p<0.0001. In the multivariate analysis, the only related factor was CD4 count <350 cell/L (OR 2.86, 95% CI 1.6-4.9; p<0.0001). IO was not associated with CVR nor with MS."

According to the news reporters, the research concluded: "IO is not uncommon in HIV patients, and it is only related with immunosuppression defined as CD4 count <350 cell/L, and in contrast to general population, it is not related with increased CVR nor with MS."

For more information on this research see: Iron overload, an immunosuppression marker in HIV-infected patients. Journal of the International Aids Society, 2012;15(6):18304. (BioMed Central - www.biomedcentral.com/; Journal of the International Aids Society - www.jiasociety.org)

Our news journalists report that additional information may be obtained by contacting C. Lopez-Calderon, Hospital Virgen de la Victoria, Malaga, Spain.

Keywords for this news article include: Spain, Malaga, Europe, HIV/AIDS, RNA Viruses, Retroviridae, Iron Overload, HIV Infections, AIDS/HIV Research, Immunosuppression, Metabolic Diseases, Vertebrate Viruses, Primate Lentiviruses, Iron Metabolism Disorders, Viral Sexually Transmitted Diseases.

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