Kaposi Sarcoma
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Research in the area of sarcoma reported from J.P. Couty and colleagues
2009 JUL 20 - (NewsRx.com) -- "A constitutively active G protein-coupled receptor (GPCR) encoded by Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) (KSHV) is expressed in endothelial (spindle) cells of Kaposi's sarcoma lesions. In this study, we report novel effects of basal signaling by this receptor and of inverse agonist chemokines on migration of KSHV-GPCR-expressing mouse lung endothelial cells," scientists in the United States report. "We show that basal signaling by KSHV-GPCR inhibits migration of endothelial cells in two systems, movement through porous filters and in vitro wound closure. Naturally occurring chemokines, interferon gamma-inducible protein-10 and stromal-derived factor-1, which act as inverse agonists at KSHV-GPCR, abrogate the inhibition of migration and stimulate directed migration (or chemotaxis) of these cells," wrote J.P. Couty and colleagues. The researchers concluded: "Thus, the expression of KSHV-GPCR may allow infected endothelial cells in situ to remain in a localized environment or to directionally migrate along a gradient of specific chemokines that are inverse agonists at KSHV-GPCR.." Couty and colleagues published their study in the Journal of Pharmacology and Experimental Therapeutics (Kaposi's Sarcoma-Associated Herpesvirus-G Protein-Coupled Receptor-Expressing Endothelial Cells Exhibit Reduced Migration and Stimulated Chemotaxis by Chemokine Inverse Agonists. Journal of Pharmacology and Experimental Therapeutics, 2009;329(3):1142-1147). For additional information, contact M.C. Gershengorn, Bldg 50, Room 4134, 50 S Dr., MSC 8029, Bethesda, MD 20892, USA. The publisher's contact information for the Journal of Pharmacology and Experimental Therapeutics is: American Society Pharmacology Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20814-3995, USA. Keywords: United States, Bethesda, Drugs, Experimental Therapeutics, Experimental Therapies, Human Herpesvirus 8, Infectious Disease, KSHV, Kaposi Sarcoma, Oncology, Pharmaceuticals, Pharmacology, Pulmonology, Respiratory Infection, Therapies, Therapy, Treatment, Virology. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
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