Ketosis
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Research from University of Sherbrooke provides new data on ketosis
2009 MAY 26 - (NewsRx.com) -- "Bentourkia M, Tremblay S, Pifferi F, Rousseau J, Lecomte R, Cunnane S. PET study of C-11-acetoacetate kinetics in rat brain during dietary treatments affecting ketosis. Am J Physiol Endocrinol Metab 296: E796-E801, 2009," researchers in Sherbrooke, Canada report. "First published January 27, 2009; doi:10.1152/ajpendo.90644.2008.-Normally, the brain's fuel is glucose, but during fasting it increasingly relies on ketones (beta-hydroxybutyrate, acetoacetate, and acetone) produced in liver mitochondria from fatty acid beta-oxidation. Although moderately raised blood ketones produced on a very high fat ketogenic diet have important clinical effects on the brain, including reducing seizures, ketone metabolism by the brain is still poorly understood. The aim of the present work was to assess brain uptake of carbon-11-labeled acetoacetate (C-11-acetoacetate) by positron emission tomography (PET) imaging in the intact, living rat. To vary plasma ketones, we used three dietary conditions: high carbohydrate control diet (low plasma ketones), fat-rich ketogenic diet (raised plasma ketones), and 48-h fasting (raised plasma ketones). C-11-acetoacetate metabolism was measured in the brain, heart, and tissue in the mouth area. Using C-11-acetoacetate and small animal PET imaging, we have noninvasively quantified an approximately seven-to eightfold enhanced brain uptake of ketones on a ketogenic diet or during fasting," wrote M. Bentourkia and colleagues, University of Sherbrooke. The researchers concluded: "This opens up an opportunity to study brain ketone metabolism in humans." Bentourkia and colleagues published their study in American Journal of Physiology - Endocrinology and Metabolism (PET study of C-11-acetoacetate kinetics in rat brain during dietary treatments affecting ketosis. American Journal of Physiology - Endocrinology and Metabolism, 2009;296(4):E796-E801). For additional information, contact M. Bentourkia, University of Sherbrooke, Dept. of Med Nuclear & Radiobiol, 3001, 12th Avenue N, Sherbrooke, PQ J1H 5N4, Canada. Publisher contact information for the American Journal of Physiology - Endocrinology and Metabolism is: American Physiological Society, 9650 Rockville Pike, Bethesda, MD 20814, USA. Keywords: Canada, Sherbrooke, Endocrinology, Ketosis, Metabolism, Physiology, Seizures, University of Sherbrooke. This article was prepared by Life Science Weekly editors from staff and other reports. Copyright 2009, Life Science Weekly via NewsRx.com.
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