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Findings from Yonsei University, Pain Research Institute broaden understanding of pneumoperitoneum therapy
2009 JUL 27 - (NewsRx.com) -- New research, 'Effect of diltiazem on kidney function during laparoscopic surgery,' is the subject of a report. "Pneumoperitoneum is known to be associated with transient impairment in kidney function. This study was designed to investigate the effect of diltiazem on acute kidney injury during positive pneumoperitoneum in patients undergoing laparoscopic surgery," scientists in Seoul, Korea report. "Thirty-two patients of American Society of Anesthesiologists (ASA) 1 and 2 physical status undergoing laparoscopic surgery were randomly divided into control (normal saline infusion) and diltiazem groups (diltiazem 2 microg/kg/min). Urinary flow, urinary sodium excretion, creatinine clearance (CrCl), and hemodynamic variables were determined during pneumoperitoneum and at postoperative 2 h. CrCl using Cockcroft-Gault equation was calculated before surgery (baseline), and at postoperative days 1 (POD1) and 2. The hemodynamic parameters were similar in both groups. CrCl during pneumoperitoneum in the diltiazem group was significantly higher than that in the control group (90.8 ±49.0 ml/min/1.73 m2 vs. 54.2 ±31.6 ml/min/1.73 m2) (p=0.026). CrCl calculated with Cockcroft-Gault equation was similar in both groups at baseline, POD1, and POD2. Urinary flow was significantly increased in both groups at postoperative 2 h compared with that during pneumoperitoneum. Continuous infusion of diltiazem 2 microg/kg/min prevented the decrease in CrCl during pneumoperitoneum without hemodynamic derangement," wrote J.Y. Kim and colleagues, Yonsei University, Pain Research Institute. The researchers concluded: "Although the decrease in CrCl was transient in patients with normal kidney function in this study, diltiazem may be used to prevent further kidney injury in those with elevated CrCl during laparoscopic surgery." Kim and colleagues published their study in Surgical Endoscopy (Effect of diltiazem on kidney function during laparoscopic surgery. Surgical Endoscopy, 2009;23(8):1785-90). For additional information, contact J.Y. Kim, Anesthesia and Pain Research Institute, Dept. of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea. The publisher's contact information for the journal Surgical Endoscopy is: Springer, 233 Spring Street, New York, NY 10013, USA. Keywords: Korea, Seoul, Pneumoperitoneum Therapy, Antihypertensive, Calcium Channel Blocker, Cardiovascular, Diltiazem, Endoscopy, Pneumoperitoneum, Surgery, Surgical Endoscopy, Therapy, Treatment, Vasodilator Agent. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
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