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New herpes simplex virus data have been reported by L.W. Tian and co-authors
2009 AUG 4 - (NewsRx.com) -- According to recent research from Kunming, People's Republic of China, "Five new 7-O-methylkaempferol and -quercetin glycosides, namely, nervili fordins A-E (1-5), were isolated from the whole plant of Nervilia fordii, together with seven known flavonoids (6, 7, and 9-13) and one known coumarin (8)." "Their structures were elucidated on the basis of extensive spectroscopic analyses, including HSQC, HMBC, ROESY, and chemical methods. Compounds 1-3 and 6-13 were evaluated for their anti-herpes simplex virus 1 (HSV-1) activity and cytotoxicity on African green monkey kidney cells (Vero cells) in vitro," wrote L.W. Tian and colleagues. The researchers concluded: "Of the tested compounds, only esculetin (8) exhibited antiviral activity against HSV-1, while the aglycones (11-13) showed stronger cytotoxicity on Vero cells than their glycosides (1-3, 6, and 7)." Tian and colleagues published their study in the Journal of Natural Products (7-O-Methylkaempferol and -quercetin Glycosides from the Whole Plant of Nervilia fordii. Journal of Natural Products, 2009;72(6):1057-1060). For additional information, contact Y.J. Zhang, Chinese Academy Science, Kunming Institute Botany, State Key Laboratory Phytochem & Plant Resources W China, Kunming 650204, People's Republic of China. Publisher contact information for the Journal of Natural Products is: American Chemical Society, 1155 16th St., NW, Washington, DC 20036, USA. Keywords: People's Republic of China, Kunming, Herpes Simplex Virus, Herpesvirus, Virology. This article was prepared by Virus Weekly editors from staff and other reports. Copyright 2009, Virus Weekly via NewsRx.com.
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