Our news journalists obtained a quote from the research from Southern Illinois University, "The studies described in this report reveal that the forkhead transcription factor, Foxd1, is not expressed in the developing mouse pituitary gland, but rather in the mesenchyme surrounding the pituitary gland, which is an essential source of signaling factors that regulate pituitary organogenesis. Loss of Foxd1 causes a morphological defect in which the anterior lobe of the pituitary gland protrudes through the cartilage plate that is developing ventral to the pituitary at embryonic days (e)14.5, e16.5, and e18.5. The number of proliferating pituitary cells is increased at e14.5 and e16.5. Loss of Foxd1 also results in significantly decreased levels of Lhb expression at e18.5. This decrease in Lhb expression does not appear to be due to a change in the number of gonadotrope cells in the pituitary gland. Previous studies have shown that loss of the LIM homeodomain factor, Lhx3, which is activated by the FGF signaling pathway, results in loss of LH production. Although there is a difference in Lhb expression in Foxd1 null mice, the expression pattern of LHX3 is not altered in Foxd1 null mice."
According to the news editors, the research concluded: "These studies suggest that Foxd1 is indirectly required for normal Lhb expression and cartilage formation."
For more information on this research see: The forkhead transcription factor, foxd1, is necessary for pituitary luteinizing hormone expression in mice. Plos One, 2012;7(12):e52156. (Public Library of Science - www.plos.org; Plos One - www.plosone.org)
The news correspondents report that additional information may be obtained from J.H. Gumbel, Dept. of Physiology, Southern Illinois University, Carbondale, Illinois, United States.
Keywords for this news article include: Illinois, Carbondale, United States, Peptide Hormones, Pituitary Hormones, Luteinizing Hormone, Life Science Research, Pituitary Gonadotropins, North and Central America, Forkhead Transcription Factors, Winged Helix Transcription Factors.
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