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Researchers' work from Korea University, Medical Department focuses on vascular endothelial growth factor
2009 AUG 24 - (NewsRx.com) -- According to recent research from Seoul, South Korea, "Regional lymph node metastases are very common findings of supraglottic cancer. The mechanism of lymphatic metastasis is as yet unknown because there have been no specific markers that could definitely distinguish lymphatic vessels from blood vessels." "The aim of this study is to identify the prognostic significance of vascular endothelial growth factor-C (VEGF-C) expression and lymphatic vessel density (LVD) in supraglottic cancer. The prognostic value of the VEGF-C and LVD was retrospectively evaluated in an unselected series of patients treated with curative intent for supraglottic cancer. We investigated lymphatic vessels in 43 subjects who had previously been diagnosed with supraglottic cancer. Immunohistochemical staining was performed with VEGF-C, D2-40, and CD31 monoclonal antibodies on the paraffin-embedded tissues obtained from these patients. The association among the semiquantitative score of VEGF-C stained cancer cells, the density of immunohistochemically stained microvessels, and the prognostic factors of supraglottic cancers were investigated to evaluate the prognostic significance. VEGF-C and LVD showed a statistically significant difference according to the presence of lymph node metastasis and regional recurrence (P <.05). VEGF-C was only associated with disease-free survival and regional recurrence in multivariate analysis (P <.05)," wrote S.K. Baek and colleagues, Korea University, Medical Department. The researchers concluded: "VEGF-C and LVD might be useful as predictors of the risk of lymph node metastasis and regional recurrence.." Baek and colleagues published their study in Laryngoscope (Prognostic Significance of Vascular Endothelial Growth Factor-C Expression and Lymphatic Vessel Density in Supraglottic Squamous Cell Carcinoma. Laryngoscope, 2009;119(7):1325-1330). For additional information, contact K.Y. Jung, Korea University, College Medical, Dept. of Otolaryngology Head & Neck Surgery, Anam Dong 5 Ga 126-1, Seoul 136705, South Korea. Publisher contact information for the journal Laryngoscope is: John Wiley & Sons Inc., 111 River St., Hoboken, NJ 07030, USA. Keywords: South Korea, Seoul, Angiogenesis, Glottic and Supraglottic Cancer, Glottic and Supraglottic Carcinoma, Laryngoscope, Lymphatic Metastasis, Medical Device, Oncology, Squamous Cell Carcinoma, VEGF, Vascular Endothelial Growth Factor, Korea University, Medical Department. This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2009, Clinical Oncology Week via NewsRx.com.
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