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Research Findings from Tufts University School of Medicine Update Understanding of Science

2013 JAN 8 (NewsRx) -- By a News Reporter-Staff News Editor at Life Science Weekly -- Fresh data on Science are presented in a new report. According to news originating from Boston, Massachusetts, by NewsRx correspondents, research stated, "Interactions between hosts and pathogens are complex, so understanding the events that govern these interactions requires the analysis of molecular mechanisms operating in both organisms. Many pathogens use multiple strategies to target a single event in the disease process, confounding the identification of the important determinants of virulence."

Our news journalists obtained a quote from the research from the Tufts University School of Medicine, "We developed a genetic screening strategy called insertional mutagenesis and depletion (iMAD) that combines bacterial mutagenesis and RNA interference, to systematically dissect the interplay between a pathogen and its host. We used this technique to resolve the network of proteins secreted by the bacterium Legionella pneumophila to promote intracellular growth, a critical determinant of pathogenicity of this organism."

According to the news editors, the research concluded: "This strategy is broadly applicable, allowing the dissection of any interface between two organisms involving numerous interactions."

For more information on this research see: Aggravating genetic interactions allow a solution to redundancy in a bacterial pathogen. Science, 2012;338(6113):1440-4. (Springer - www.springer.com; Science - www.springerlink.com/content/0926-7220/)

The news correspondents report that additional information may be obtained from T.J. O'Connor, Howard Hughes Medical Institute and Dept. of Molecular Microbiology and Microbiology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, United States.

Keywords for this news article include: Boston, Science, Massachusetts, United States, North and Central America, Bacterial Infections and Mycoses.

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