Researchers from Case Western Reserve University, Department of Neurosciences report recent findings in life sciences
2007 NOV 20 -- Investigators publish new data in the report 'Galanin plays a role in the conditioning lesion effect in sensory neurons.' According to a study from the United States, "Sensory neurons show enhanced neurite outgrowth in vivo and in vitro following a conditioning lesion. Previous studies have shown that these effects are dependent on two members of the gp130 family of cytokines, leukemia inhibitory factor and interleukin-6." "Here, we asked whether galanin, a neuropeptide induced by these cytokines, plays a role in the conditioning lesion response. Following a conditioning lesion, neurite outgrowth in culture was reduced in sensory neurons from galanin -/-mice compared with those from wild type controls. In neurons from wild type mice, the length of the longest neurite was increased 2.4-fold after a conditioning lesion, compared with 1.8-fold in neurons from knockout animals," wrote H.H. Sachs and colleagues, Case Western Reserve University, Department of Neurosciences. The researchers concluded: "The results indicate that the induction of galanin plays an important role in triggering the conditioning lesion response." Sachs and colleagues published the results of their research in NeuroReport (Galanin plays a role in the conditioning lesion effect in sensory neurons. NeuroReport, 2007;18(16):1729-33). For additional information, contact H.H. Sachs, Case Western Reserve University, Dept. of Neurosciences, Cleveland Ohio USA.. The publisher of the journal NeuroReport can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St., Philadelphia, PA 19106-3621, USA. Keywords: United States, Life Sciences. This article was prepared by Life Science Weekly editors from staff and other reports. Copyright 2007, Life Science Weekly via NewsRx.com.
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