Lewy Body Disease
Return to Library
|
Free Lewy Body Disease Articles |
|
|
|
|
New research on life sciences from Sun Health Research Institute summarized
2009 JUN 1 - (NewsRx.com) -- Scientists discuss in 'Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction' new findings in life sciences. According to recent research published in the journal Acta Neuropathologica, "The two current major staging systems in use for Lewy body disorders fail to classify up to 50% of subjects. Both systems do not allow for large numbers of subjects who have Lewy-type alpha-synucleinopathy (LTS) confined to the olfactory bulb or who pass through a limbic-predominant pathway that at least initially bypasses the brainstem." "The results of the current study, based on examination of a standard set of ten brain regions from 417 subjects stained immunohistochemically for alpha-synuclein, suggest a new staging system that, in this study, allows for the classification of all subjects with Lewy body disorders. The autopsied subjects included elderly subjects with Parkinson's disease, dementia with Lewy bodies, incidental Lewy body disease and Alzheimer's disease with Lewy bodies, as well as comparison groups without Lewy bodies. All subjects were classifiable into one of the following stages: I. Olfactory Bulb Only; IIa Brainstem Predominant; IIb Limbic Predominant; III Brainstem and Limbic; IV Neocortical. Progression of subjects through these stages was accompanied by a generally stepwise worsening in terms of striatal tyrosine hydroxylase concentration, substantia nigra pigmented neuron loss score, Mini Mental State Examination score and score on the Unified Parkinson's Disease Rating Scale Part 3. Additionally, there were significant correlations between these measures and LTS density scores," wrote T.G. Beach and colleagues, Sun Health Research Institute. The researchers concluded: "It is suggested that the proposed staging system would improve on its predecessors by allowing classification of a much greater proportion of cases." Beach and colleagues published their study in Acta Neuropathologica (Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction. Acta Neuropathologica, 2009;117(6):613-34). For additional information, contact T.G. Beach, Sun Health Research Institute, Sun City, AZ 85351 USA.. The publisher's contact information for the journal Acta Neuropathologica is: Springer, 233 Spring Street, New York, NY 10013, USA. Keywords: United States, Sun City, Life Sciences, Dementia, Central Nervous System Disease, Lewy Body Disease, Parkinson Disease, Alzheimer Disease. This article was prepared by Pain & Central Nervous System Week editors from staff and other reports. Copyright 2009, Pain & Central Nervous System Week via NewsRx.com.
|
