Lichen Sclerosus
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Recent studies from City Hospital add new data to squamous cell carcinoma
2009 AUG 3 - (NewsRx.com) -- In this recent article published in the International Journal of Gynecological Cancer, scientists in Birmingham, the United Kingdom conducted a study "To assess the potential malignant risk of vulval premalignant conditions, ill particular, to investigate whether there is a difference in the cancer risk between women with the 2 types of vulval intraepithelial neoplasia (VIN). All vulval biopsy specimens taken for any reason in a single center for a 5-year period were identified." "The histologic reports of 1309 biopsy specimens from 802 women were reviewed, and all pathologic conditions present were recorded for each woman. Reports of patients with biopsy specimens containing usual-type VIN, differentiated-type VIN, lichen sclerosus, and squamous hyperplasia were selected and analyzed for the presence of metachronous or subsequent carcinoma to give a proportional risk for each condition. Five hundred eighty women were identified with premalignant vulval conditions: 171 had usual-type VIN, 70 had differentiated-type VIN, 19 1 had lichen sclerosus, 145 had squamous hyperplasia, and 3 had other conditions not included in this analysis. Within these groups, the numbers of women with prior, synchronous, or subsequent vulval squamous cell carcinoma were 44 (25.7%), 60 (85.7%) 53 (27.7%), and 53 (31.7%), respectively (P = 0.000)," wrote L.J. Eva and colleagues, City Hospital. The researchers concluded: "Differentiated-type VIN is significantly more associated with vulval squamous cell carcinoma than usual-type VIN.." Eva and colleagues published their study in International Journal of Gynecological Cancer (Differentiated-Type Vulval Intraepithelial Neoplasia Has a High-Risk Association With Vulval Squamous Cell Carcinoma. International Journal of Gynecological Cancer, 2009;19(4):741-744). Additional information can be obtained by contacting L.J. Eva, City Hospital, Dept. of Gynecology Oncology, Pan Birmingham Cancer Center, Dudley Rd., Birmingham B18 7QH, W Midlands, UK. The publisher of the International Journal of Gynecological Cancer can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St., Philadelphia, PA 19106-3621, USA. Keywords: United Kingdom, Birmingham, Biopsy, Cancer, Gynecology, Hyperplasia, Lichen Sclerosus, Neoplasia, Oncology, Squamous Cell Carcinoma, Surgery, City Hospital. This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2009, Clinical Oncology Week via NewsRx.com.
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