Lipodystrophy
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Study data from S. Mercier and colleagues update understanding of HIV/AIDS
2009 JUL 13 - (NewsRx.com) -- In this recent study, researchers in Montpellier, France conducted a study "To assess adverse effects of long-term highly active antiretroviral therapy (HAART), that is, lipodystrophy and metabolic disorders, in a cohort of African patients. One hundred eighty HIV-1-infected patients treated with HAART for 4-9 years in Dakar and 180 age-matched and sex-matched controls were enrolled." "Regional subcutaneous fat changes were assessed by physicians, and fasting blood samples were drawn. Centralization of body fat was estimated using skinfold ratio, waist circumference, and waist to hip ratio (WHR). Mean duration of HAART was 5.4 years. Main drugs received were zidovudine, stavudine, and protease inhibitors. The prevalence of moderate-severe lipodystrophy was 31.1% (95% confidence interval: 24.3 to 37.9), with 13.3%, 14.5%, and 3.3% for lipoatrophy, lipohypertrophy, and mixed forms, respectively. Mild-severe lipodystrophy affected 65.0% (58.0; 72.0) of patients. Stavudine was the only independent risk factor (any vs. none: odds ratio = 2.8; 1.4 to 5.5). had lower body mass index and skinfolds but greater centralization of body fat (WHR, P< 0.0001 and skinfold ratio, P< 0.001), fasting glucose (P < 0.0001), homeostasis model assessment insulin resistance, and triglyceride levels (P < 0.01 for both) than controls. Moderately-severely lipodystrophic patients had higher triglyceride and low-density lipoprotein cholesterol than other patients (P < 0.001 and P< 0.05, respectively)," wrote S. Mercier and colleagues. The researchers concluded: "Moderate-severe lipodystrophy affected one third of West African patients on long-term HAART and was associated with a less favorable metabolic profile." Mercier and colleagues published their study in Jaids - Journal of Acquired Immune Deficiency Syndromes (Lipodystrophy and Metabolic Disorders in HIV-1-Infected Adults on 4-to 9-Year Antiretroviral Therapy in Senegal: A Case-Control Study. Jaids - Journal of Acquired Immune Deficiency Syndromes, 2009;51(2):224-230). For more information, contact K.B. Simondon, Center IRD Montpellier, 911 Avenue Agropolis, BP 64501, F-34590 Montpellier 5, France. Publisher contact information for the Jaids - Journal of Acquired Immune Deficiency Syndromes is: Lippincott Williams & Wilkins, 530 Walnut St., Philadelphia, PA 19106-3621, USA. Keywords: France, Montpellier, HIV/AIDS, AIDS, Acquired Immune Deficiency Syndrome, Acquired Immunodeficiency Syndrome, Alternative Medicine, Antivirals, Clinical Trial Research, Drugs, Endocrinology, Enzyme Research, Enzymes, Enzymology, HAART, HIV, Human Immunodeficiency Virus, Immunology, Lipodystrophy, Metabolic Disorders, Nucleoside Reverse Transcriptase Inhibitor, Pharmaceuticals, Protease Inhibitor, Protease Inhibitors, Proteins, Proteomics, Sexually Transmitted Disease, Stavudine, Therapy, Treatment, Virology, Zidovudine. This article was prepared by Anti-Infectives Week editors from staff and other reports. Copyright 2009, Anti-Infectives Week via NewsRx.com.
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