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Study findings on sepsis are outlined in reports from T.T. Logters and colleagues
2009 AUG 3 - (NewsRx.com) -- "Kynurenine, the major degradation product of tryptophan has been shown to directly damage tissues, but its possible contribution to posttraumatic morbidity is unknown. Here, we studied the kinetics of kynurenine in patients after major trauma and whether this correlates with the development of posttraumatic sepsis," investigators in Dusseldorf, Germany report. "Kynurenine and tryptophan levels of 60 multiple-injured patients with Injury Severity Score of more than 16 were quantified prospectively by high-performance liquid chromatography. Blood samples were obtained daily from admission until day 10 after admission. Significantly increased kynurenine values were detectable already at day 1 after admission in blood from patients who later developed sepsis, regardless of injury pattern (P < 0.01). In contrast, kynurenine values of nonsepsis patients remained low throughout the observation period. However, all patients exhibited significantly decreased tryptophan values versus healthy controls (P < 0.01). Moreover, significantly increased kynurenine-tryptophan ratios rapidly predicted subsequent sepsis, multiple organ failure, and death (P < 0.01). Both increased kynurenine values and kynurenine-tryptophan ratios predicted posttraumatic development of sepsis and organ failure," wrote T.T. Logters and colleagues. The researchers concluded: "This ought to be validated in subsequent studies.." Logters and colleagues published their study in Shock (INCREASED PLASMA KYNURENINE VALUES AND KYNURENINE-TRYPTOPHAN RATIOS AFTER MAJOR TRAUMA ARE EARLY INDICATORS FOR THE DEVELOPMENT OF SEPSIS. Shock, 2009;32(1):29-34). For additional information, contact M. Scholz, University of Hospital Dusseldorf, Dept. of Trauma & Hand Surgery, Moorenstr 5, D-40225 Dusseldorf, Germany. The publisher of the journal Shock can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St., Philadelphia, PA 19106-3621, USA. Keywords: Germany, Dusseldorf, Bloodstream Infection, Diagnosis, Diagnostics, Liquid Chromatography, Multiple Organ Failure, Sepsis, Septicemia. This article was prepared by Hematology Week editors from staff and other reports. Copyright 2009, Hematology Week via NewsRx.com.
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