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Study findings from J.G. Gomeznunez et al broaden understanding of intracorporeal lithotripter
2009 MAY 11 - (NewsRx.com) -- According to recent research from Zapopan, Mexico, "Renal calculi may contain bacteria that can remain active inside the stone and produce bacteremia and/or endotoxemia after lithotripsy. Urinary tract infection associated with urinary stones represents high morbidity." "The purpose of this research was to use novel artificial struvite stones inoculated with living bacteria and to study the effect of four different intracorporeal lithotripters on bacterial inactivation after in vitro lithotripsy. Two types of artificial kidney stone models (calcium sulphate and mixed struvite-calcium sulphate) were manufactured and infected with Proteus mirabilis. Stones were fractured using either electrohydraulic, laser, ultrasonic, or pneumatic lithotripters. Bacterial viability was determined before and after the lithotripsy. Bacterial inactivation was not affected by the stone matrix; ie, calcium or struvite. The four tested lithotripters were almost equally efficient at reducing the viability of P mirabilis in both the low and the high energy setting. We were able to obtain novel artificial struvite stones infected with bacteria. Intracorporeal lithotripters are efficient at reducing the viability of P mirabilis in vitro. Tested stone materials play a minor role regarding inactivation," wrote J.G. Gomeznunez and colleagues. The researchers concluded: "Whether the bactericidal effect reported is desirable or not is still to be answered, because the presence of endotoxin from cell lysis may increase the risk of urosepsis." Gomeznunez and colleagues published their study in the Journal of Endourology (Interaction of Intracorporeal Lithotripters with Proteus mirabilis Inoculated Inside Artificial Calcium and Struvite Stones. Journal of Endourology, 2009;23(3):519-522). For additional information, contact J.G. Gomeznunez, Hospital Puerta Hierro, Institute Endourol, Blvd. Puerta Hierro 5150-406 Torre B, Zapopan 45116, Jal, Mexico. Publisher contact information for the Journal of Endourology is: Mary Ann Liebert Inc., 140 Huguenot Street, 3RD FL, New Rochelle, NY 10801, USA. Keywords: Mexico, Zapopan, Artificial Kidney, Bacteremia, Bioengineering, Biomedical Engineering, Biomedicine, Endotoxemia, Endourology, Intracorporeal Lithotripter, Kidney Calculi, Medical Device, Nephrology, Proteus, Renal Calculi, Urinary Tract Infection, Urology. This article was prepared by Cardiovascular Week editors from staff and other reports. Copyright 2009, Cardiovascular Week via NewsRx.com.
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