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New data from University of Rouen illuminate research in hepatitis C virus
2009 AUG 17 - (NewsRx.com) -- According to a study from Rouen, France, "Liver biopsy is considered the gold-standard method for the assessment of liver fibrosis during follow-up of hepatitis C virus-infected patients, but this invasive procedure is not devoid of complications. The aim of the present study was to identify novel non-invasive markers of fibrosis progression." "By microarray analysis, we compared transcript levels in two extreme stages of fibrosis from 16 patients. Informative transcripts were validated by real-time PCR and used for the assessment of fibrosis in 23 additional patients. Sixteen transcripts were found to be dysregulated. during the fibrogenesis process. Among them, some were of great interest because their corresponding proteins could be serologically measured. Thus, the protein levels of inter-alpha inhibitor H1, serpin peptidase inhibitor clade F member 2, and transthyretin were all significantly different according to the four Metavir stages of fibrosis," wrote F. Caillot and colleagues, University of Rouen. The researchers concluded: "We report here that dysregulation, at both the transcriptional and protein levels, exists during the fibrogenesis process. Our description of three novel serum markers and their potential use as serological tests for the non-invasive diagnosis of liver fibrosis open new opportunities for better follow-up of hepatitis C virus-infected patients. (Am J Pathol 2009, 175:46-53; DOI: 10.2353/ajpath.2009.080850)." Caillot and colleagues published the results of their research in American Journal of Pathology (Novel Serum Markers of Fibrosis Progression for the Follow-Up of Hepatitis C Virus-infected Patients. American Journal of Pathology, 2009;175(1):46-53). For additional information, contact F. Caillot, University of Rouen, INSERM, Unite 905, Faculty Med Pharmacy, 22 Bvd Gambetta, F-76183 Rouen, France. The publisher of the American Journal of Pathology can be contacted at: American Society Investigative Pathology, Inc., 9650 Rockville Pike, Bethesda, MD 20814-3993, USA. Keywords: France, Rouen, Biopsy, Gastroenterology, HCV, Hepatitis C Virus, Hepatology, Infectious Disease, Liver Cirrhosis, Liver Fibrosis, Pathology, Surgery, Virology, University of Rouen. This article was prepared by Gastroenterology Week editors from staff and other reports. Copyright 2009, Gastroenterology Week via NewsRx.com.
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