University of Ioannina, Department of Chemistry publishes research in cancer therapy
2007 NOV 19 -- Data detailed in 'Synthesis and antitumor activity of peptide-paclitaxel conjugates' have been presented. According to recent research published in the Journal of Peptide Science, "Paclitaxel (Pac) is the most important anticancer drug used mainly in treatment of breast, lung, and ovarian cancer and is being investigated for use as a single agent for treatment of lung cancer, advanced head and neck cancers, and adenocarcinomas of the upper gastrointestinal tract. In this work, we present the synthesis of five 2'-paclitaxel-substituted analogs in which paclitaxel was covalently bound to peptides or as multiple copies to synthetic carriers." "Ac-Cys(CH(2)CO-2'-Pac)-Arg-Gly-Asp-Arg-NH(2), Folyl-Cys(CH(2)CO-2'-Pac)-Arg-Gly-Asp-Ser-NH(2), Ac-[Lys-Aib-Cys(CH(2)CO-2'-Pac)](2)-NH(2), Ac-[Lys-Aib-Cys(CH(2)CO-2'-Pac)](3)-NH(2) and Ac-[Lys-Aib-Cys(CH(2)CO-2'-Pac)](4)-NH(2) were synthesized using 2'-halogeno-acetylated paclitaxel derivatives. Paclitaxel conjugates showed greater solubility in water than paclitaxel and inhibited the proliferation of human breast, prostate, and cervical cancer cell lines," wrote S. Papas and colleagues, University of Ioannina, Department of Chemistry. The researchers concluded: "Although all synthesized compounds had an antiproliferative activity, the Ac-[Lys-Aib-Cys(CH(2)CO-2'-Pac)](4)-NH(2) derivative showed improved biological activity in comparison with paclitaxel in cervical and prostate human cancer cells." Papas and colleagues published their study in the Journal of Peptide Science (Synthesis and antitumor activity of peptide-paclitaxel conjugates. Journal of Peptide Science, 2007;13(10):662-71). For additional information, contact S. Papas, University of Ioannina, Dept. of Chemistry, GR-45110 Ioannina, Greece. The publisher's contact information for the Journal of Peptide Science is: John Wiley & Sons Ltd., the Atrium, Southern Gate, Chichester PO19 8SQ, W Sussex, England. Keywords: Greece, Ioannina, Anticancer Therapy, Antitumor Activity, Cancer, Drugs, Infectious Disease, Oncology, Paclitaxel, Peptide, Peptide Science, Pharmaceuticals, Proteins, Proteomics, Pulmonology, Respiratory Infection, Treatment. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2007, Biotech Business Week via NewsRx.com.
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