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New Alimentary Pharmacology Study Results Reported from I. Maguilnik et al

2012 NOV 5 (NewsRx) -- By a News Reporter-Staff News Editor at Gastroenterology Week -- Investigators discuss new findings in Alimentary Pharmacology. According to news reporting originating from Dallas, Texas, by NewsRx correspondents, research stated, "The epidemiology of reactive gastropathy and its relationship with other conditions of the gastrointestinal tract associated with NSAID use have not been evaluated. To test the hypothesis that if reactive gastropathy shares common aetiological factors with these conditions, the analysis of a large cohort would unveil associations."

Our news editors obtained a quote from the research, "We queried a national pathology database for subjects with a diagnosis of reactive gastropathy; controls were patients with normal gastric biopsies. We also extracted diagnoses of H. pylori infection, intestinal metaplasia, duodenal lymphocytosis, duodenitis, ileitis, microscopic colitis and focal colitis. Of 504 011 patients with gastric biopsies, 69 101 had oesophageal, 166 134 duodenal, 13 010 ileal and 83 334 colonic biopsies. Reactive gastropathy was diagnosed in 15.6% of patients, H. pylori infection in 10.3% and normal gastric mucosa in 16.3%. Reactive gastropathy was evenly distributed across the US and increased from 2.0% in the first decade of life to >20% in octogenarians. Compared with controls, reactive gastropathy was significantly associated with Barrett's mucosa (OR 1.21 95% CI 1.16129); duodenitis (OR 1.36; 95% CI 1.281.44); duodenal intraepithelial lymphocytosis (OR 1.25; 95% CI 1.131.39); active ileitis (OR 1.88; 95% CI 1.472.40); focal active colitis (OR 1.57; 95% CI 1.331.86); and collagenous colitis (OR 1.50; 95% CI 1.122.03). Reactive gastropathy, a common histopathological feature of the stomach, shows an age-dependent rise and is associated with changes of the digestive tract believed to be caused by NSAID use or duodenogastric reflux."

According to the news editors, the research concluded: "However, a large fraction of reactive gastropathy remains unexplained; its frequent occurrence merits further efforts at elucidating its aetiology."

For more information on this research see: Reactive gastropathy is associated with inflammatory conditions throughout the gastrointestinal tract. Alimentary Pharmacology & Therapeutics, 2012;36(8):736-743. Alimentary Pharmacology & Therapeutics can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Alimentary Pharmacology & Therapeutics - onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2036)

The news editors report that additional information may be obtained by contacting I. Maguilnik, Dallas VA Med Center, Dallas, TX, United States.

Keywords for this news article include: Texas, Dallas, Colitis, United States, Gastroenteritis, Colonic Diseases, Gastroenterology, Alimentary Pharmacology, North and Central America, Digestive System Diseases, Gastrointestinal Diseases

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