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Researchers from Tokyo Women's Medical University detail new studies and findings in the area of systemic sclerosis
2009 JUN 1 - (NewsRx.com) -- "Patients with systemic sclerosis (SSc) complicated by severe gastrointestinal tract (GIT) dysmotility at an early stage are difficult to treat and mortality is high. To clarify the pathogenesis of GIT involvement, the occurrence of autoantibody was investigated for muscarinic-3 acetylcholine receptor (M3R) in patients with SSc," scientists in Tokyo, Japan report. "Fourteen patients with severe GIT involvement ( malabsorption syndrome and/or pseudo-obstruction) within 2 years of SSc onset ( group 1) were enrolled in the present study. Sixty-two patients with SSc without severe GIT involvement within 2 years of onset ( group 2) were also recruited, along with 70 healthy control subjects. Using an established enzyme immunoassay (EIA) system detecting autoantibody against the second loop domain of M3R, the presence of an anti-M3R antibody was examined in SSc patients. The mean optical density ( OD) titres of group 1 were significantly higher than those of group 2 (0.65 ( SD 0.58) vs 0.066 (SD 0.13), p<0.001). The positivity of anti-M3R antibody was significantly higher in group 1 than in group 2 (9/14 vs 3/62, p = 2.5 x 10(-6) by Fisher's exact test). The cutoff OD was calculated from the EIA reaction of the 70 healthy controls ( the mean value plus 2 SD was 0.295)," wrote Y. Kawaguchi and colleagues, Tokyo Women's Medical University. The researchers concluded: "The findings indicated that anti-M3R antibody very frequently appears in patients with SSc, which is accompanied by severe GIT involvement, suggesting that M3R-mediated enteric cholinergic neurotransmission may provide a pathogenic mechanism for GIT dysmotility in SSc." Kawaguchi and colleagues published their study in Annals of the Rheumatic Diseases (Muscarinic-3 acetylcholine receptor autoantibody in patients with systemic sclerosis: contribution to severe gastrointestinal tract dysmotility. Annals of the Rheumatic Diseases, 2009;68(5):710-714). For more information, contact Y. Kawaguchi, Tokyo Women's Medical University, Institute Rheumatol, Shinjuku Ku, 10-22 Kawada Cho, Tokyo 1620054, Japan. Publisher contact information for the journal Annals of the Rheumatic Diseases is: B M J Publishing Group, British Med Association House, Tavistock Square, London WC1H 9JR, England. Keywords: Japan, Tokyo, Gastroenterology, Immunoassay, Malabsorption Syndrome, Rheumatic Disease, Systemic Scleroderma, Systemic Sclerosis, Tokyo Women's Medical University. This article was prepared by Gastroenterology Week editors from staff and other reports. Copyright 2009, Gastroenterology Week via NewsRx.com.
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