Matrix Metalloproteinase
Return to Library
|
Free Matrix Metalloproteinase Articles |
|
|
|
|
Report summarizes breast cancer study findings from S.M. Eck and co-researchers
2009 AUG 3 - (NewsRx.com) -- "Matrix metalloproteinase-1 (MMP-1) is critical for mediating breast cancer metastasis to bone. We investigated the role of MMP-1 in breast cancer invasion of soft tissues and bone using human MDA MB-231 breast cancer cells stably transfected with shRNAs against MMP-1 and a novel murine model of bone invasion," researchers in Lebanon report. "MMP-1 produced by breast cancer cells with control shRNA facilitated invasion of tumors into soft tissue in vivo, which correlated with enhanced blood vessel formation at the invasive edge, compared to tumors with silenced MMP-1 expression. Tumors expressing MMP-1 were also associated with osteolysis in vivo, whereas tumors with inhibited MMP-1 levels were not. Additionally, tumor-secreted MMP-1 activated bone-resorbing osteoclasts in vitro. Together, these data suggest a mechanism for MMP-1 in the activation of osteoclasts in vivo," wrote S.M. Eck and colleagues. The researchers concluded: "Breast cancer-derived MMP-1 mediates invasion through soft tissues and bone via mechanisms involving matrix degradation, angiogenesis, and osteoclast activation.." Eck and colleagues published their study in Breast Cancer Research and Treatment (Matrix metalloproteinase-1 promotes breast cancer angiogenesis and osteolysis in a novel in vivo model. Breast Cancer Research and Treatment, 2009;116(1):79-90). For additional information, contact C.E. Brinckerhoff, Norris Cotton Cancer Center, Dept. of Medical, 1 Med Center Dr., Rubin Bldg, HB 7936, Lebanon, NH 03756, USA. Publisher contact information for the journal Breast Cancer Research and Treatment is: Springer, 233 Spring St., New York, NY 10013, USA. Keywords: Lebanon, Angiogenesis, Blood Vessel Formation, Bone, Breast Cancer, Breast Carcinoma, Cancer Research, Enzyme Research, Matrix Metalloproteinase, Metalloproteinases, Oncology, Osteolysis, Proteins, Proteomics, Tumor Vascularization, Women's Health. This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2009, Clinical Oncology Week via NewsRx.com.
|
