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Study findings on diagnostics are outlined in reports from University Hospital
2009 JUL 27 - (NewsRx.com) -- Fresh data on diagnostics are presented in the report 'Clinical and diagnostic value of ribosomal P autoantibodies in systemic lupus erythematosus.' According to a study from Sfax, Tunisia, "To analyse prospectively the diagnostic sensitivity and specificity as well as the clinical relevance of ribosomal P (anti-P) autoantibodies in a large cohort of SLE patients. The anti-P autoantibodies were evaluated in the serum of 200 Tunisian SLE patients at disease onset and 130 various control subjects by a sensitive immunodot assay." "A complete laboratory evaluation and clinical examination were performed in each SLE patient. During the follow-up, the patients were regularly monitored for clinical parameters. Global SLE activity was measured by the ECLAM. The sensitivity and specificity of anti-P testing for SLE were 23.5 and 98.4%, respectively. The anti-P-positive samples 14/47 (29.8%), 27/47 (57.4%) and 5/47 (10.6%) were negative for anti-dsDNA, anti-Sm or both antibodies, respectively. The anti-P-positive patients showed more active disease activity and a much higher prevalence of arthritis. An association between IgG aCLs and anti-P antibodies was also found. However, anti-P antibodies were not associated with neuropsychiatric manifestations or lupus nephritis. This study does not seem to confirm the described association of anti-P antibodies with neuropsychiatric manifestations of SLE. However, it supports the anti-P antibody association with arthritis and disease activity as well as the presence of aCL," wrote S. Haddouk and colleagues, University Hospital. The researchers concluded: "Based on our study and other related studies, we propose that, akin to anti-Sm and anti-dsDNA, anti-P antibodies detected by one agreed method may be considered for inclusion as a criterion for the classification of SLE." Haddouk and colleagues published the results of their research in Rheumatology (Clinical and diagnostic value of ribosomal P autoantibodies in systemic lupus erythematosus. Rheumatology, 2009;48(8):953-7). For additional information, contact S. Haddouk, Habib Bourguiba University Hospital of Sfax, Immunology Laboratory, Sfax, Tunisia. The publisher of the journal Rheumatology can be contacted at: Oxford University Press, Great Clarendon St., Oxford OX2 6DP, England. Keywords: Tunisia, Sfax, Diagnostics, Rheumatology, Systemic Lupus Erythematosus. This article was prepared by Gastroenterology Week editors from staff and other reports. Copyright 2009, Gastroenterology Week via NewsRx.com.
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