Nephroblastoma
Return to Library
|
Free Nephroblastoma Articles |
|
|
|
|
New Wilms' tumor research reported from Charite University
2009 JUL 20 - (NewsRx.com) -- "Blood vessel formation is important for normal organ development and tumour growth. A highly specialised developmental program of vessel formation exists in the heart and is essential for normal cardiogenesis," scientists in Berlin, Germany report. "From mouse models, it became clear that the Wilms' tumour protein Wt1 is required for normal heart development. Originally identified as a tumour suppressor gene based on its mutational inactivation in Wilms' tumour or nephroblastoma, Wt1 is nowadays recognised to have much broader functions in organogenesis and pathophysiology. The multiple tasks of Wt1 are not only limited to the kidney but involve the heart and vascular system as well. In this review, we focus on recent findings about the importance of Wt1 in heart and coronary vessel development and the identified molecular mechanisms," wrote H. Scholz and colleagues, Charite University. The researchers concluded: "In addition, we discuss the implication of Wt1 in the vascular response to myocardial ischaemia and its oncogenic potential as a promoter of tumour angiogenesis.." Scholz and colleagues published their study in Pflugers Archiv - European Journal of Physiology (Role of the Wilms' tumour transcription factor, Wt1, in blood vessel formation. Pflugers Archiv - European Journal of Physiology, 2009;458(2):315-323). For additional information, contact H. Scholz, Charite University, Institute Vegetat Physiol, Tucholskystr 2, D-10117 Berlin, Germany. The publisher's contact information for the Pflugers Archiv - European Journal of Physiology is: Springer, 233 Spring St., New York, NY 10013, USA. Keywords: Germany, Berlin, Angiogenesis, Biotechnology, Blood Vessel Formation, Cardiology, Gene Therapy, Genetics, Genomics, Nephroblastoma, Oncology, Physiology, Tumor Suppression, Tumor Vascularization, Wilms Tumor, Wilms' Tumor, Charite University. This article was prepared by Cardiovascular Week editors from staff and other reports. Copyright 2009, Cardiovascular Week via NewsRx.com.
|
