Oral Lichen Planus
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Scientists at Sichuan University, West China College of Stomatology describe research in oral lichen planus
2009 JUN 2 - (NewsRx.com) -- New investigation results, 'IFN-gamma and IL-4 in saliva of patients with oral lichen planus: a study in an ethnic Chinese population,' are detailed in a study published in Inflammation. "Interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) represent T helper 1 (Th1) and T helper 2 (Th2) cytokines involved in oral lichen planus (OLP), respectively. This study was to investigate the expression profile of IFN-gamma and IL-4 in saliva of OLP patients," scientists in Chengdu, People's Republic of China report. "Seventy-nine ethnic Chinese patients with OLP were recruited for this study, together with 41 age-sex-matched healthy volunteers served as control group. IFN-gamma and IL-4 levels in whole unstimulated saliva were screened by enzyme linked immunosorbent assay. OLP patient showed a low-level IFN-gamma but high-level IL-4 expression profile in saliva, with a lower ratio of salivary IFN-gamma/IL-4 compared to healthy controls. With regards to subtypes, salivary IL-4 level in erythematous/ulcerative group was significantly higher than that in reticular group. Imbalance of Th1/Th2 cytokines with Th2-predominant profile in saliva may be involved in OLP," wrote W. Liu and colleagues, Sichuan University, West China College of Stomatology. The researchers concluded: "Salivary IL-4 level may be a fine biomarker reflecting the severity of OLP." Liu and colleagues published their study in Inflammation (IFN-gamma and IL-4 in saliva of patients with oral lichen planus: a study in an ethnic Chinese population. Inflammation, 2009;32(3):176-81). For additional information, contact W. Liu, State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, Sichuan, China. The publisher's contact information for the journal Inflammation is: Springer, 233 Spring Street, New York, NY 10013, USA. Keywords: People's Republic of China, Chengdu, Cytokines, Dermatology, Inflammation, Oral Lichen Planus. This article was prepared by Life Science Weekly editors from staff and other reports. Copyright 2009, Life Science Weekly via NewsRx.com.
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