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New findings reported from Memorial Sloan Kettering Cancer Center, Department of Surgery describe advances in gynecologic cancer prevention
2007 NOV 19 -- Data detailed in 'Screening and prevention of hereditary gynecologic cancers' have been presented. "Endometrial and ovarian cancer are the fourth and fifth most common malignancies in women, with approximately 40,000 new endometrial and 25,000 new ovarian cancers expected to be diagnosed in the Unites States this year. While the majority of these cancers will occur in the absence of a family history, approximately 5% of endometrial cancers and 10% of ovarian cancers will be the result of inherited defects in high-penetrance cancer susceptibility genes," scientists writing in the journal Seminars In Oncology report. "With the identification and subsequent availability of clinical genetic testing for mutations in the genes associated with hereditary breast-ovarian cancer and the Lynch/hereditary nonpolyposis colorectal cancer (HNPCC) syndrome, targeted risk-reduction using intensive screening, chemoprevention, and prophylactic surgery has become possible for women at inherited risk of gynecologic malignancies. We review the options for gynecologic cancer risk reduction in women with an inherited mutation in BRCA1, BRCA2, or one of the mismatch repair (MMR) genes associated with Lynch/HNPCC syndrome," wrote S.M. Kehoe and colleagues, Memorial Sloan Kettering Cancer Center, Department of Surgery. The researchers concluded: "Additionally, we outline ongoing questions and areas for future research." Kehoe and colleagues published their study in Seminars In Oncology (Screening and prevention of hereditary gynecologic cancers. Seminars In Oncology, 2007;34(5):406-10). Additional information can be obtained by contacting S.M. Kehoe, Gynecology Service, Dept. of Surgery, Memorial Sloan-Kettering Cancer Center, New York City, NY 10021 USA.. The publisher of the journal Seminars In Oncology can be contacted at: W B Saunders Co., Independence Square West Curtis Center, Ste. 300, Philadelphia, PA 19106-3399, USA. Keywords: United States, New York, Gynecologic Cancer Prevention, Gynecologic Cancer, Gynecology, Oncology, Ovarian Cancer, Ovarian Carcinoma, Women's Health. This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2007, Clinical Oncology Week via NewsRx.com.
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