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University of Torino reports research in brain cancer
2009 AUG 24 - (NewsRx.com) -- According to recent research published in the journal Radiologia Medica, "This study was undertaken to correlate apparent diffusion coefficient (ADC) and relative regional cerebral blood volume (rrCBV) to histological findings in a large series of patients with primary or secondary brain tumours to evaluate diffusion-weighted (DWI) and perfusionweighted (PWI) imaging in the characterisation of cerebral tumors. Ninety-eight patients with cerebral tumours, 46 of which were primary (seven grade 0-I, nine low-grade gliomas, two gliomatosis cerebri, nine lymphomas and 19 high-grade gliomas) and 52 secondary, underwent conventional magnetic resonance (MR) imaging completed with DWI and dynamic contrast susceptibility PWI." "Both ADC and rrCBV were calculated on a workstation by using Functool 2 software. Student's t test was used to determine any statistically significant differences in the ADC and rrCBV values. Seventeen of 98 tumours were cystic or necrotic (12/17 hypointense and 5/17 hyperintense on DWI); the ADC value of hyperintense cystic areas was 0.97 +/- 0.23x10(-3) mm(2)/s. The ADC value of solid tumours varied between 0.64 and 3.5x10(-3) mm(2)/s. The rrCBV value was 1.4 (sigma 0.66) in low-grade gliomas; 1.22 (sigma 0.25) in lymphomas; 4.5 (sigma 0.85) in grade III gliomas; 3.18 (sigma 1.26) in grade IV gliomas and 2.53 (sigma 1.6) in metastases. DWI has an important role in the differential diagnosis of cystic cerebral masses but not in tumour characterisation," wrote L. Rizzo and colleagues, University of Torino. The researchers concluded: "PWI is helpful in differentiating high-from low-grade gliomas and lymphomas from high-grade gliomas.." Rizzo and colleagues published their study in Radiologia Medica (Role of diffusion- and perfusion-weighted MR imaging for brain tumour characterisation. Radiologia Medica, 2009;114(4):645-659). For additional information, contact L. Rizzo, University of Torino Sede San Luigi, Ist Radiol, Orbassano, Italy. The publisher's contact information for the journal Radiologia Medica is: Springer, 233 Spring St., New York, NY 10013, USA. Keywords: Italy, Orbassano, Brain Cancer, Brain Carcinoma, Gliomatosis, Hematology, Lymphoma, Magnetic Resonance, Oncology, Perfusion, University of Torino. This article was prepared by Pain & Central Nervous System Week editors from staff and other reports. Copyright 2009, Pain & Central Nervous System Week via NewsRx.com.
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