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Data on endometriosis genetics described by researchers at Medical University of Bialystok
2009 JUL 27 - (NewsRx.com) -- A new study, 'Expression of selected tumor suppressor and oncogenes in endometrium of women with endometriosis,' is now available. "It is becoming increasingly evident that the eutopic endometrium of women with endometriosis shows certain genetic alterations which are not found in the endometrium of disease-free women. The aim of the study was to compare the expression level of mammalian target of rapamycin (mTOR) tumor suppressor and oncogene-related genes in the endometrium of women with and without endometriosis as well as in ovarian endometriosis," scientists writing in the journal Human Reproduction report. "A total of 81 regularly menstruating patients were recruited in the study. We applied the micro fluidic gene array to examine the expression of 15 human tumor suppressor and oncogenes in eutopic endometrium of 40 women with endometriosis and 41 controls without endometriosis. In 14 patients with endometriosis, gene expression was also studied in matched ovarian lesions. We studied the following genes: NF1, RHEB, mTOR, PTEN, TSC1, TSC2, KRAS, S6K1, TP53, EIF4E, LKB1, PIK3CA, BECN1, 4EBP1 and AKT1. Immunohistochemical studies were subsequently performed for selected proteins. Of the 15 studied genes, we found significantly higher levels of oncogene AKT1 (p=0.006) and tumor suppressor gene 4EBP1 (p=0.01) mRNAs in the eutopic endometrium of women with endometriosis compared with control patients. Immunohistochemistry showed that 4EBP1 and AKT1 proteins were expressed in eutopic endometrium," wrote P. Laudanski and colleagues, Medical University of Bialystok. The researchers concluded: "Our results suggest that up-regulation of AKT1 and 4EBP1 in eutopic endometrium may be associated with the pathogenesis of endometriosis, but their precise role remains to be established." Laudanski and colleagues published their study in Human Reproduction (Expression of selected tumor suppressor and oncogenes in endometrium of women with endometriosis. Human Reproduction, 2009;24(8):1880-90). Additional information can be obtained by contacting P. Laudanski, Medical University of Bialystok, Dept. of Perinatology, ul Marii Sklodowskiej-Curie 24a, Bialystok, Poland. The publisher of the journal Human Reproduction can be contacted at: Oxford University Press, Great Clarendon St., Oxford OX2 6DP, England. Keywords: Poland, Bialystok, Endometriosis Genetics, Endometriosis, Genetics, Gynecology, Oncology, Tumor Suppression. This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2009, Clinical Oncology Week via NewsRx.com.
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