Pneumococcal Vaccine
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Research from Children's Hospital, Department of Microbiology in the area of pneumococcal disease vaccines published
2007 JUL 2 -- New research, "Pneumococci responsible for invasive disease and discharging ears in children in Sydney, Australia," is the subject of a report. According to recent research from Westmead, Australia, "The serotypes and molecular clones of penicillin-nonsusceptible Streptococcus pneumoniae (PNSP) responsible for invasive pneumococcal disease (IPD) and discharging ears in metropolitan New South Wales were characterized to form a baseline prior to introduction of the heptavalent conjugate pneumococcal vaccine in Australia. Pneumococci isolated between 1 July 2000 and 30 June 2003 in Sydney from children <15 years were tested for antibiotic susceptibilities and serotyped." "Penicillin-nonsusceptible pneumococci were typed by multilocus sequence typing and BOX PCR. During this period, 97 (13.9 %) of 698 pneumococci from IPD that were serotyped were penicillin-nonsusceptible. Of 607 pneumococci from discharging ears, 157 (26.1 %) were penicillin-nonsusceptible. Serotype 14 was the predominant serotype responsible for IPD and serotype 19F predominated from discharging ears. The heptavalent vaccine serotypes accounted for 613 (87.8 %) of all invasive isolates and 420 (69.8 %) of all isolates from discharging ears. Representatives of the major international clones were present among the PNSP. The majority of serotypes and clones that showed penicillin-nonsusceptibility are present within the vaccine. Serotype switching was also noted to have occurred prior to introduction of the vaccine. This study provides a characterization of the pneumococcal serotypes associated with IPD and discharging ears that will be useful for detecting potential selective effects of the vaccine," wrote M. Watson and colleagues, Children's Hospital, Department of Microbiology. The researchers concluded: "This surveillance should be continued, as it will be important to monitor the frequency and distribution of serotypes in the post-vaccine era." Watson and colleagues published their study in the Journal of Medical Microbiology (Pneumococci responsible for invasive disease and discharging ears in children in Sydney, Australia. Journal of Medical Microbiology, 2007;56(Pt 6):819-23). For additional information, contact M. Watson, The Children's Hospital at Westmead, Dept. of Microbiology, The Children's Hospital at Westmead, Westmead, New South Wales, Australia. Publisher contact information for the Journal of Medical Microbiology is: Society General Microbiology, Marlborough House, Basingstoke Rd., Spencers Woods, Reading RG7 1AG, Berks, England. Keywords: Australia, Westmead, Pneumococcal Disease Vaccines, Biotechnology, Drugs, Microbiology, Penicillin G Potassium, Pharmaceuticals, Pneumococcal, Therapy, Treatment, Vaccines. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2007, Biotech Business Week via NewsRx.com.
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