Reactive Arthritis


Research reports on chlamydia from C.H. Henry and colleagues provide new insights



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This article was published in Pain & Central Nervous System Week, which you can subscribe to online.
2007 OCT 22 -- "'Objective. The objective of this study was to determine if temporomandibular joint (TMJ) samples positive for Chlamydia trachomatis have a greater presence of tumor necrosis factor-alpha (TNF alpha) or interleukin-6 (IL-6) when compared with Chlamydia-negative samples. Posterior bilaminar tissue samples removed during TMJ surgery from 70 patients were evaluated," scientists in Milan, Italy report.

"Cryosections were stained using monoclonal antibody that identifies C. trachomatis. The presence of IL-6 and TNF alpha were evaluated by immunostaining in 15 samples positive and in 25 samples negative for the presence of C. trachomatis. Of the 70 TMJ samples, 32 (46%) were positive for C. trachomatis. In 15 samples positive for C. trachomatis, 10 (67%) were positive for TNF alpha and 7 (47%) for IL-6," wrote C.H. Henry and colleagues.

The researchers concluded: "In 25 samples negative for C. trachomatis, only 4 (16%) were positive for TNF alpha and only 2 (8%) for IL-6. Differences in C. trachomatis-positive samples versus negative were significant for both TNF alpha (P < .002) and IL-6 (P < .008). The presence of C. trachomatis in the TMJ is associated with a significantly increased presence of TNF and IL-6."

Henry and colleagues published their study in Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology (Reactive arthritis and internal derangement of the temporomandibular joint. Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, 2007;104(1):E22-E26).

For more information, contact C.H. Henry, Ist Stomatol Italiano, Via Pace 21, I-20122 Milan, Italy.

Publisher contact information for the journal Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology is: Mosby-Elsevier, 360 Park Avenue South, New York, NY 10010-1710, USA.

Keywords: Italy, Milan, Biotechnology, Chlamydia Trachomatis, Gynecology, Infectious Disease, Medical Device, Monoclonal Antibody, Necrosis, Ophthalmology, Oral Medicine, Oral Pathology, Oral Surgery, Radiology, Reactive Arthritis, Rheumatology, Sexually Transmitted Disease, TMJ, Temporomandibular Joint Dysfunction Syndrome, Women's Health's.

This article was prepared by Pain & Central Nervous System Week editors from staff and other reports. Copyright 2007, Pain & Central Nervous System Week via NewsRx.com.