Reactive Arthritis


Data from C.W. Ang and colleagues advance knowledge in reactive arthritis



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This article was published in Pain & Central Nervous System Week, which you can subscribe to online.
2007 OCT 1 -- Scientists discuss in "Validation of an ELISA for the diagnosis of recent Campylobacter infections in Guillain-Barré and reactive arthritis patients" new findings in reactive arthritis. "Weeks or months following Campylobacter infection, a small proportion of infected individuals develop Guillain-Barré syndrome (GBS) or reactive arthritis (ReA). Stool culture for Campylobacter is often negative in these patients, and serology is therefore the method of choice for diagnosing a recent infection with Campylobacter," scientists in Delft, Netherlands report.

"This study developed a capture ELISA system to detect anti-Campylobacter IgA and IgM antibodies indicative of a recent infection. The sensitivity of the assay was 82.0% in uncomplicated Campylobacter enteritis patients, 96.2% in GBS patients who were culture-positive for Campylobacter, and 93.1% in culture-positive ReA patients, with a specificity of 93.0%," wrote C.W. Ang and colleagues, .

The researchers concluded: "The assay allows identification of Campylobacter infection in patients with post-infectious neurological and rheumatological complications."

Ang and colleagues published their study in Clinical Microbiology and Infection (Validation of an ELISA for the diagnosis of recent Campylobacter infections in Guillain-Barré and reactive arthritis patients. Clinical Microbiology and Infection, 2007;13(9):915-22).

For additional information, contact C.W. Ang, Dept. of Medical Microbiology, Dept. of Medical Microbiology, Amsterdam, Reinier de Graad Gasthuis, Reinier de Graad Gasthuis, Delft, Netherlands.

The publisher's contact information for the journal Clinical Microbiology and Infection is: Blackwell Publishing Ltd., 9600 Garsington Rd., Oxford OX4 2DG, Oxon, England.

Keywords: Netherlands, Delft, Campylobacter, Clinical Microbiology, Diagnosis, Diagnostics, Reactive Arthritis, Rheumatology.

This article was prepared by Pain & Central Nervous System Week editors from staff and other reports. Copyright 2007, Pain & Central Nervous System Week via NewsRx.com.