Respiratory Syncytial Virus
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Studies from T. Okabayashi et al further understanding of anti-infectives
2009 AUG 10 - (NewsRx.com) -- "Respiratory syncytial virus (RSV) infects airway epithelial cells, causing bronchiolitis and pneumonia. Inflammation is mediated by various cytokines secreted from RSV-infected airway epithelial cells, and it promotes the pathogenesis of RSV-related diseases," scientists in Sapporo, Japan report. "Fosfomycin (FOF) is approved as a treatment for various bacterial infectious diseases, including respiratory infectious diseases, in Japan. FOF is suggested to exhibit immunomodulatory effects on lipopolysaccharide-stimulated monocytes and T lymphocytes, in addition to its antimicrobial activity. We investigated the effect of FOF on the cytokine production of an airway epithelial cell line, A549, infected with RSV. RSV-induced cytokines, such as regulated on activation, normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and IL-6, in infected A549 cells. We found that FOF decreased the levels of RSV-induced RANTES and IL-8 but not the level of RSV-induced IL-6. The RANTES promoter was activated by RSV infection. Site-directed mutagenesis analysis of the RANTES promoter showed that NF-kappa B-binding motifs had a critical role in RSV-induced RANTES promoter activity. A luciferase reporter gene assay and a DNA-binding assay indicated that FOF suppressed the NF-kappa B activity induced by RSV infection," wrote T. Okabayashi and colleagues. The researchers concluded: "These results demonstrate that FOF treatment suppresses the RSV-induced transcription of the chemokines RANTES and IL-8 in airway epithelial cells.." Okabayashi and colleagues published their study in Clinical and Vaccine Immunology (Fosfomycin Suppresses Chemokine Induction in Airway Epithelial Cells Infected with Respiratory Syncytial Virus. Clinical and Vaccine Immunology, 2009;16(6):859-865). For more information, contact N. Fujii, Sapporo Med University, School Medical, Dept. of Microbiology, Chuou Ku, S1-W17, Sapporo, Hokkaido 0608556, Japan. Publisher contact information for the journal Clinical and Vaccine Immunology is: American Society Microbiology, 1752 N St. NW, Washington, DC 20036-2904, USA. Keywords: Japan, Sapporo, Anti-Infectives, Antimicrobial, Antimicrobials, Biotechnology, Bronchiolitis, Cytokines, Fosfomycin, Immunology, Infectious Disease, Inflammation, Pulmonology, Respiratory Syncytial Virus, Vaccines. This article was prepared by Anti-Infectives Week editors from staff and other reports. Copyright 2009, Anti-Infectives Week via NewsRx.com.
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