Study results from University of Iowa, Department of Microbiology broaden understanding of respiratory syncytial virus vaccines
2007 NOV 13 -- A report, 'CD8 T cells inhibit respiratory syncytial virus (RSV) vaccine-enhanced disease,' is newly published data in The Journal of Immunology. According to a study from the United States, "Vaccination of children with a formalin-inactivated (FI) respiratory syncytial virus (RSV) vaccine led to exacerbated disease including pulmonary eosinophilia following a natural RSV infection. Immunization of BALB/c mice with FI-RSV or a recombinant vaccinia virus (vv) expressing the RSV attachment (G) protein (vvG) results in a pulmonary Th2 response and eosinophilia after RSV challenge that closely mimics the RSV vaccine-enhanced disease observed in humans." "The underlying causes of RSV vaccine-enhanced disease remain poorly understood. We demonstrate here that RSV M2-specific CD8 T cells reduce the Th2-mediated pathology induced by vvG-immunization and RSV challenge in an IFN-gamma-independent manner. We also demonstrate that FI-RSV immunization does not induce a measurable RSV-specific CD8 T cell response and that priming FI-RSV-immunized mice for a potent memory RSV-specific CD8 T cell response abrogates pulmonary eosinophilia after subsequent RSV challenge," wrote M.R. Olson and colleagues, University of Iowa, Department of Microbiology. The researchers concluded: "Our results suggest that the failure of the FI-RSV vaccine to induce a CD8 T cell response may have contributed to the development of pulmonary eosinophilia and augmented disease that occurred in vaccinated individuals." Olson and colleagues published the results of their research in the Journal of Immunology (CD8 T cells inhibit respiratory syncytial virus (RSV) vaccine-enhanced disease. Journal of Immunology, 2007;179(8):5415-24). For additional information, contact M.R. Olson, University of Iowa, Dept. of Microbiology, IA 52242 USA.. The publisher of the Journal of Immunology can be contacted at: American Association Immunologists, 9650 Rockville Pike, Bethesda, MD 20814, USA. Keywords: United States, Respiratory Syncytial Virus Vaccines, Biotechnology, Eosinophilia, Immunology, Infectious Disease, Pulmonology, Respiratory Syncytial Virus, Vaccines, Vaccinia Virus, Viral. This article was prepared by Life Science Weekly editors from staff and other reports. Copyright 2007, Life Science Weekly via NewsRx.com.
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