Retinoblastoma

Research data from St. Paul's Hospital update understanding of heart bypass surgery

Retinoblastoma Library Library Home This article was published in Cardiovascular Week, which you can subscribe to online.

"We investigated the effect of diabetes on cell cycle, proliferation signaling, and the activation of matrix metalloproteinases (MMPs). Segments of internal mammary arteries from 26 type 2 diabetic and 26 non-diabetic patients undergoing coronary artery bypass grafting surgery were compared. Increased levels of cyclin D1 mRNA (by 135±14%) and protein expression (by 93.8±7.0%), retinoblastoma protein phosphorylation (by 45.9±4.8%), and beta-catenin nuclear localization (by 176±16%) indicated the enhanced cell cycle entry in the diabetic arteries. Diabetes increased phosphorylation of extracellular signal-regulated kinase-1/2 and p-38-mitogen-activated protein kinase (MAPK) by 76.0±6.8 and 62.3±4.3%," wrote A.W. Chung and colleagues, St. Paul's Hospital.

The researchers concluded: "Increased collagen deposition was evidenced in the diabetic arteries. mRNA levels of MMP-1 and MMP-3 were decreased in the diabetic tissue to 55 and 82%, respectively, compared to the non-diabetic group; protein levels were also decreased accompanied with decreased enzymatic activities by 21 and 50%, respectivelyenhanced cell cycle entry, increased MAPK signaling, and downregulated MMP-1 and MMP-3 were characteristic of diabetic arterial vasculature, and could contribute to the progressive atherosclerosis and postangioplasty restenosis in diabetic patients."

Chung and colleagues published their study in Atherosclerosis (Enhanced cell cycle entry and mitogen-activated protein kinase-signaling and downregulation of matrix metalloproteinase-1 and -3 in human diabetic arterial vasculature. Atherosclerosis, 2007;195(1):e1-8).

For more information, contact A.W. Chung, St. Paul's Hospital, The James Hogg iCAPTURE Center for the Cardiovascular and Pulmonary Research, Canada.

Publisher contact information for the journal Atherosclerosis is: Elsevier Science Ireland Ltd., Customer Relations Manager, Bay 15, Shannon Industrial Estate, Co. Clare, Ireland.

Keywords: Canada, Heart Bypass Surgery, Atherosclerosis, Cardiology, Cell Biology, Coronary Artery Bypass Graft, Coronary Disease, Diabetes, Endocrinology, Enzyme Research, Heart Disease, Kinase, Matrix Metalloproteinase, Medical Device, Metalloproteinases, Protein Expression, Proteins, Proteomics, Surgery, Surgical Technology.

This article was prepared by Cardiovascular Week editors from staff and other reports. Copyright 2007, Cardiovascular Week via NewsRx.com.