Study findings on tissue engineering are outlined in reports from University of Nottingham
2007 NOV 13 -- New investigation results, 'Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritis,' are detailed in a study published in Annals of the Rheumatic Diseases. According to recent research from Nottingham, the United Kingdom, "Normal adult articular cartilage is thought to be avascular and aneural To describe neurovascular structures at the osteochondral junction and in osteophytes in tibiofemoral osteoarthritis (OA) displaying a range of severity of cartilage changes Articular surfaces were obtained from 40 patients at total knee joint replacement surgery for tibiofemoral OA (TKR) and seven patients post mortem (PM). Antibodies directed against CD34 (vascular endothelium), protein gene product 9.5 (pan-neuronal marker), substance P and calcitonin gene-related peptide (sensory nerves) and C-flanking peptide of neuropeptide Y (sympathetic nerves) were used to localise blood vessels and nerves by immunohistochemistry." "Severity of OA cartilage changes was graded histologically TKR and PM samples displayed a range of OA cartilage changes including tidemark breaching by vascular channels. Sympathetic and sensory nerves were both present within vascular channels in the articular cartilage, in both mild and severe OA. Perivascular and free nerve fibres, and nerve trunks were observed within the subchondral bone marrow and within the marrow cavities of osteophytes," wrote S. Suri and colleagues, University of Nottingham. The researchers concluded: "Sensory and sympathetic nerves displayed similar distributions in each region studied Vascularisation and the associated innervation of articular cartilage may contribute to tibiofemoral pain in OA across a wide range of structural disease severity." Suri and colleagues published their study in Annals of the Rheumatic Diseases (Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritis. Annals of the Rheumatic Diseases, 2007;66(11):1423-8). For additional information, contact S. Suri, City Hospital, Academic Rheumatology, University of Nottingham, Hucknall Road, Nottingham, Notts NG5 1PB, UK. Publisher contact information for the journal Annals of the Rheumatic Diseases is: B M J Publishing Group, British Med Association House, Tavistock Square, London WC1H 9JR, England. Keywords: United Kingdom, Nottingham, Joint Replacement, Medical Device, Osteoarthritis, Rheumatic Disease, Surgery, Surgical Technology, Tissue Engineering. This article was prepared by Life Science Weekly editors from staff and other reports. Copyright 2007, Life Science Weekly via NewsRx.com.
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