Researchers from Loughborough University, Department of Human Sciences report on findings in arthritis
2007 NOV 19 -- A new study, 'Association of PTPN22 with rheumatoid arthritis among South Asians in the UK,' is now available. In this recently published article, scientists in Loughborough, the United Kingdom conducted a study "To compare the distribution and assess genetic associations of the PTPN22 R620W single-nucleotide polymorphism among South Asian (Asiatic Indian) patients with rheumatoid arthritis (RA) and ethnically matched controls DNA samples from 133 rheumatoid factor-positive South Asian RA patients and 149 control subjects from the East Midlands of the UK were genotyped for PTPN22 R620W polymorphism." "Genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism method The PTPN22 *T allele frequency was lower than in the Caucasian populations, but the disease association was significant (odds ratio 5.87, 95% confidence interval 1.68-20.52)," wrote S. Mastana and colleagues, Loughborough University, Department of Human Sciences. The researchers concluded: "Similar association was observed for genotypes containing *T allele Our results suggest that the T variant acts as a susceptibility allele for autoantibody-positive RA among South Asians." Mastana and colleagues published their study in the Journal of Rheumatology (Association of PTPN22 with rheumatoid arthritis among South Asians in the UK. Journal of Rheumatology, 2007;34(10):1984-6). For more information, contact S. Mastana, Loughborough University, Dept. of Human Sciences, Loughborough, UK. Publisher contact information for the Journal of Rheumatology is: J Rheumatol Publ Co., 920 Yonge St., Suite 115, Toronto, Ontario M4W 3C7, Canada. Keywords: United Kingdom, Loughborough, Arthritis, Rheumatoid Arthritis, Rheumatology. This article was prepared by Pain & Central Nervous System Week editors from staff and other reports. Copyright 2007, Pain & Central Nervous System Week via NewsRx.com.
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