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New sarcoma research from L. Daltongriffin and colleagues discussed
2009 AUG 24 - (NewsRx.com) -- According to recent research from London, the United Kingdom, "Kaposi's sarcoma-associated herpesvirus (KSHV), like other herpesviruses, has two stages to its life cycle: latency and lytic replication. KSHV is required for development of Kaposi's sarcoma, a tumor of endothelial origin, and is associated with the B-cell tumor primary effusion lymphoma (PEL) and the plasmablastic variant of multicentric Castleman's disease, all of which are characterized by predominantly latent KSHV infection." "Recently, we and others have shown that the activated form of transcription factor X-box binding protein 1 (XBP-1) is a physiological trigger of KSHV lytic reactivation in PEL. Here, we show that XBP-1s transactivates the ORF50/RTA promoter though an ACGT core containing the XBP-1 response element, an element previously identified as a weakly active hypoxia response element (HRE). Hypoxia induces the KSHV lytic cycle, and active HREs that respond to hypoxia-inducible factor 1 alpha are present in the ORF50/RTA promoter," wrote L. Daltongriffin and colleagues. The researchers concluded: "Hypoxia also induces active XBP-1s, and here, we show that both transcription factors contribute to the induction of RTA expression, leading to the production of infectious KSHV under hypoxic conditions.." Daltongriffin and colleagues published their study in the Journal of Virology (X-Box Binding Protein 1 Contributes to Induction of the Kaposi's Sarcoma-Associated Herpesvirus Lytic Cycle under Hypoxic Conditions. Journal of Virology, 2009;83(14):7202-7209). For additional information, contact P. Kellam, UCL, Dept. of Infection, Virus Genom & Informat Group, 46 Cleveland St., London W1T 4JF, UK. Publisher contact information for the Journal of Virology is: American Society Microbiology, 1752 N St. NW, Washington, DC 20036-2904, USA. Keywords: United Kingdom, London, Hematology, Herpesvirus, Human Herpesvirus 8, KSHV, Kaposi Sarcoma, Lymphoma, Oncology, Physiology, Virology. This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2009, Clinical Oncology Week via NewsRx.com.
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