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Reports outline carcinoma study findings from Charles University
2009 JUN 8 - (NewsRx.com) -- "Previous studies suggested that mutant beta-catenin gene cells in cutaneous adnexal tumors with matrical differentiation contribute to their tumorigenesis. Except for pilomatricoma and pilomatrical carcinoma, only a handful of other cutaneous adnexal tumor types have been studied," scientists in Plzen, Czech Republic report. "DNA was extracted from 86 lesions including 17 proliferating tricholemmal and trichilemmal tumors, 15 trichoblastomas, 7 trichoadenomas, 4 pilomatricomas, I pilomatrical carcinoma, 4 basal cell carcinomas (BCCs) with shadow cells, 2 trichofolliculomas, 3 BCCs with sebaceous differentiation, 9 sebaceous adenomas, 6 sebaceomas, 14 sebaceous carcinomas (both ocular and extraocular forms), 2 gigantic horns, and 2 apocrine mixed tumors with shadow cells and subjected to polymerase chain reaction with newly designed primers encompassing glycogen synthase kinase-3beta phosphorylation sites of the CTNNB1 gene. Also, 3 craniopharyngiomas were studied. Sequenced polymerase chain reaction products for possible beta-catenin gene mutations showed a total of 8 alterations. These included 5 different point mutations, 3 of them identified in 2 different tumors: S23N (cribriform trichoblastoma), D32Y (pilomatricoma and craniopharyngioma), G34R (pilomatrical carcinoma and craniopharyngioma), S37F (2 BCCs with shadow cell differentiation), and G34V (craniopharyngioma)," wrote D.V. Kazakov and colleagues, Charles University. The researchers concluded: "This study broadens the list of cutaneous adnexal tumors harboring CTNNB1 mutations and extends the listing of the mutations occurring in these neoplasms." Kazakov and colleagues published their study in American Journal of Dermatopathology (Mutations in Exon 3 of the CTNNB1 Gene (Beta-Catenin Gene) in Cutaneous Adnexal Tumors. American Journal of Dermatopathology, 2009;31(3):248-255). For more information, contact D.V. Kazakov, Charles University Prague, Medical Faculty Hospital, Sikls Dept. of Pathology, Alej Svobody 80, Plzen 30460, Czech Republic. Publisher contact information for the American Journal of Dermatopathology is: Lippincott Williams & Wilkins, 530 Walnut St., Philadelphia, PA 19106-3621, USA. Keywords: Czech Republic, Plzen, Adenoma, Basal Cell Cancer, Basal Cell Carcinoma, Craniopharyngioma, DNA, Dermatopathology, Endocrinology, Oncology, Pathology, Sebaceous Cancer, Sebaceous Carcinoma, Trichoepithelioma, Charles University. This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2009, Clinical Oncology Week via NewsRx.com.
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