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New neurogenetic study results from C.D. Clelland et al described
2009 AUG 3 - (NewsRx.com) -- According to recent research published in the journal Science, "The dentate gyrus (DG) of the mammalian hippocampus is hypothesized to mediate pattern separation-the formation of distinct and orthogonal representations of mnemonic information-and also undergoes neurogenesis throughout life. How neurogenesis contributes to hippocampal function is largely unknown." "Using adult mice in which hippocampal neurogenesis was ablated, we found specific impairments in spatial discrimination with two behavioral assays: (i) a spatial navigation radial arm maze task and (ii) a spatial, but non-navigable, task in the mouse touch screen. Mice with ablated neurogenesis were impaired when stimuli were presented with little spatial separation, but not when stimuli were more widely separated in space," wrote C.D. Clelland and colleagues. The researchers concluded: "Thus, newborn neurons may be necessary for normal pattern separation function in the DG of adult mice." Clelland and colleagues published their study in Science (A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation. Science, 2009;325(5937):210-213). For additional information, contact F.H. Gage, Salk Institute Biology Studies, Genetics Laboratory, 10010 N Torrey Pines Rd., La Jolla, CA 92037, USA. The publisher's contact information for the journal Science is: American Association Advancement Science, 1200 New York Avenue, NW, Washington, DC 20005, USA. Keywords: United States, La Jolla, Neurogenetic, Neurogenesis, Separation Science. This article was prepared by Pain & Central Nervous System Week editors from staff and other reports. Copyright 2009, Pain & Central Nervous System Week via NewsRx.com.
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