Studies from Charite University yield new information about sickle cell anemia
2007 NOV 12 -- Research findings, 'Total and free Mg2+ contents in erythrocytes: a simple but still undisclosed cell model,' are discussed in a new report. According to recent research published in the journal Magnesium Research, "The concentration of intracellular free Mg2+ ([Mg2+]i) in erythrocytes, measured by means of 31P NMR and using a dissociation constant for MgATP of 38-50 microM, amounted to 0.2 mM [Mg2+]i in the erythrocytes of various species, was not significantly different and was independent of their total Mg2+ content. The more probable value of [Mg2+]i using the more realistic KD of Mg ATP or the null-point method may amount to 0.4 mM [Mg2+]i in erythrocytes is lower than the [Mg2+]i in nucleated mammalian cell types." "The lower [Mg2+]i may be caused by a different regulation of Mg2+ influx and Mg2+ efflux by intracellular Mg2+ in erythroblasts. Free and reversibly bound Mg2+ represent a Mg2+ buffer. The main Mg2+-binding substances are ATP and 2,3-bisphosphoglycerate (2,3-BPG). Total Mg2+ content in the erythrocytes of various species is correlated to the concentrations of ATP and 2,3-BPG," wrote T. Günther and colleagues, Charite University. The researchers concluded: "The changed Mg2+ level in erythrocytes during deoxygenation, maturation, cold storage, in Mg2+ deficiency and in sickle cell anemia was reviewed." Günther and colleagues published their study in Magnesium Research (Total and free Mg2+ contents in erythrocytes: a simple but still undisclosed cell model. Magnesium Research, 2007;20(3):161-7). For additional information, contact T. Günther, Charite-Universitatsmedizin Berlin, Campus Benjamin Franklin, Institut fur Molekularbiologie und Biochemie, Arnimallee 22, 14195 Berlin, Germany. The publisher's contact information for the journal Magnesium Research is: John Libbey & Co. Ltd., 13 Smiths Yard, Summerley St., London SW18 4HR, England. Keywords: Germany, Berlin, Cell Biology, Hematology, Sickle Cell Anemia, Sickle Cell Disease. This article was prepared by Hematology Week editors from staff and other reports. Copyright 2007, Hematology Week via NewsRx.com.
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