Researchers from University of Utah, Department of Neurology provide details of new studies and findings in the area of spinal muscular atrophy clinical trial
2007 OCT 8 -- A report, 'Perspectives on clinical trials in spinal muscular atrophy,' is newly published data in Journal of Child Neurology. "Spinal muscular atrophy is one of the most heterogeneous of the single-gene neuromuscular disorders. The broad spectrum of severity, with onset from the prenatal period to adulthood, presents unique challenges in the design and implementation of clinical trials," investigators in the United States report. "The clinical classification of subjects into severe (type 1), intermediate (type 2), and mild (type 3) subtypes has proved useful both in enhancing communication among clinicians internationally and in forging the collaborative development of outcome measures for clinical trials. Ideally, clinical trial design in spinal muscular atrophy must take into account the spinal muscular atrophy type, patient age, severity-of-affection status, nature of the therapeutic approach, timing of the proposed intervention relative to disease progression, and relative homogeneity of the cohort to be studied," wrote K.J. Swoboda and colleagues, University of Utah, Department of Neurology. The researchers concluded: "Following is an overview of the challenges and opportunities, current and future therapeutic strategies, and progress to date in clinical trials in spinal muscular atrophy.'." Swoboda and colleagues published their study in the Journal of Child Neurology (Perspectives on clinical trials in spinal muscular atrophy. Journal of Child Neurology, 2007;22(8):957-66). For additional information, contact K.J. Swoboda, University of Utah School of Medicine, Dept. of Neurology, Salt Lake City, Utah 84132 USA.. The publisher of the Journal of Child Neurology can be contacted at: B C Decker Inc., 20 Hughson St. South, PO Box 620, L C D 1, Hamilton, Ontario L8N 3K7, Canada. Keywords: United States, Salt Lake City, Spinal Muscular Atrophy Clinical Trial, Charcot-Marie-Tooth Disease, Child Neurology, Clinical Trial Research, Neurology, Spinal Muscular Atrophy. This article was prepared by Pain & Central Nervous System Week editors from staff and other reports. Copyright 2007, Pain & Central Nervous System Week via NewsRx.com.
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