Study data from Zhejiang University, Clinical Research Institute update knowledge of stem cell research
2007 NOV 19 -- New investigation results, 'Heregulin protects mesenchymal stem cells from serum deprivation and hypoxia-induced apoptosis,' are detailed in a study published in Molecular and Cellular Biochemistry. "Heregulin can regulate the survival of cardiomyocytes, epithelial cells, neuron, glial cells, and other cell types through binding with the ErbB receptors. The aim of this study is to investigate the effects of heregulin (HRG) on the apoptosis of Bone marrow Mesenchymal stem cells (MSCs)," scientists in Hangzhou, People's Republic of China report. "We used the MSCs from adult Sprague-Dawley rats and the model of serum deprivation (SD) and hypoxia-induced apoptosis. The apoptosis was detected by TUNEL method. The apoptosis of MSCs significantly increased 12 h or 18 h after SD and hypoxia, but treatment with HRG significantly decreased the apoptosis induced by SD and hypoxia. Tyrphostin AG1478 (ErbB3/4 inhibitor) or Tyrphostin AG825 (ErbB2 inhibitor) could block this effects of HRG. Akt and ERK were activated by HRG under SD and hypoxia conditions, but HRG had no effects on the activation of JNK and p38. HRG also increased the ratio of Bcl-2/Bax and decreased the activation of caspase3 induced by SD and hypoxia," wrote C. Gui and colleagues, Zhejiang University, Clinical Research Institute. The researchers concluded: "These results suggested HRG could decrease the apoptosis of MSCs induced by SD and hypoxia through the activation of Akt and ERK, the increase of Bcl-2/Bax ratio and the inhibition of caspase3 activation." Gui and colleagues published their study in Molecular and Cellular Biochemistry (Heregulin protects mesenchymal stem cells from serum deprivation and hypoxia-induced apoptosis. Molecular and Cellular Biochemistry, 2007;305(1-2):171-8). For additional information, contact C. Gui, Affiliated Sir Run Run Shaw Hospital, Clinical Research Institute, College of Medicine, Zhejiang University, Hangzhou, 310016, PR China. The publisher's contact information for the journal Molecular and Cellular Biochemistry is: Kluwer Academic Publ, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. Keywords: People's Republic of China, Hangzhou, Apoptosis, Bone, Cell Biology, Cellular Biochemistry, Clinical Research, Stem Cell Research. This article was prepared by Stem Cell Week editors from staff and other reports. Copyright 2007, Stem Cell Week via NewsRx.com.
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