Study data from University Hospital, Division of Hematology update understanding of cardiovascular disease risk factors
2007 NOV 19 -- Fresh data on cardiovascular disease are presented in the report 'Premature cardiovascular disease after allogeneic hematopoietic stem-cell transplantation.' According to a study from Basel, Switzerland, "We assessed incidence and risk factors of cardiovascular events in 265 patients undergoing allogeneic hematopoietic stem-cell transplantation (HSCT) between 1980 and 2000 and who survived at least 2 years. Results were compared with a cohort of 145 patients treated during the same period with autologous HSCT." "The median age of patients with allogeneic HSCT at last follow-up was 39 years, and median follow-up was 9 years. Eighteen (6.8%) patients after allogeneic and 3 (2.1%) patients after autologous HSCT experienced an arterial event. The cumulative incidence of first arterial event after allogeneic HSCT was 22.1% (95% CI, 12.0-40.9) at 25 years. The cumulative incidence 15 years after allogeneic HSCT was 7.5% as compared with 2.3% after autologous HSCT. Adjusting for age, risk of an arterial event was significantly higher after allogeneic HSCT (RR 6.92; p=.009). In multivariate analysis, allogeneic HSCT (RR: 14.5; p=.003), and at least 2 of 4 cardiovascular risk factors (hypertension, dyslipidemia, diabetes, obesity) (RR: 12.4; p=.02) were associated with a higher incidence of arterial events after HSCT. Thus, long-term survivors after allogeneic HSCT are at high risk for premature arterial vascular disease," wrote A. Tichelli and colleagues, University Hospital, Division of Hematology. The researchers concluded: "HSCT might favor the emergence of established risk factors, such as hypertension, diabetes, and dyslipidemia." Tichelli and colleagues published the results of their research in Blood (Premature cardiovascular disease after allogeneic hematopoietic stem-cell transplantation. Blood, 2007;110(9):3463-71). For additional information, contact A. Tichelli, University Hospital, Division of Hematology, Petersgraben 4, CH-4031 Basel, Switzerland. The publisher of the journal Blood can be contacted at: American Society Hematology, 1900 M Street. NW Suite 200, Washington, DC 20036, USA. Keywords: Switzerland, Basel, Cardiovascular Disease Risk Factors, Cardiology, Cardiovascular Disease, Hematology, Hematopoietic, Stem Cell Research. This article was prepared by Cardiovascular Week editors from staff and other reports. Copyright 2007, Cardiovascular Week via NewsRx.com.
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