Studies conducted at La Laguna University, Medical Department on stem cell research recently published
2007 NOV 19 -- "In occluded femoral artery segments, intimal thickening occurred and abundant neovascularization from the surrounding microcirculation developed. Under these conditions, the contribution of vasa-vasorum as a source of supplementary population of cells during the early intimal thickening formation was studied," scientists writing in the journal Histology and Histopathology report. "Using a technique that specifically labels venules, predominantly postcapillary venules, a marker-Monastral Blue B-was used as a tracer to follow the pericyte, endothelial cell and monocyte/macrophage lineages. In the first two days of the experiment, the marker was restricted to the wall of the periarterial microcirculation, being incorporated by endothelial cells, pericytes and some monocytes/macrophages crossing the venule walls. Later, the marker continues to be observed in some of the following cells: endothelial cells and pericytes of the newly-formed vessels, fibroblast- like cells, transitional cells between pericytes and fibroblast-like cells, macrophages migrating into the interstitium, myointimal cells and neoendothelial cells of the arterial lumen," wrote L. Diazflores and colleagues, La Laguna University, Medical Department. The researchers concluded: "These findings provide evidence that, during arterial intimal thickening formation in occluded arterial segments, the periarterial microvascularization contributes, in addition to recruited macrophages, newly-formed endothelial cells and a supplementary population of fibroblast-like cells and myointimal cells." Diazflores and colleagues published their study in Histology and Histopathology (Cell contribution of vasa-vasorum to early arterial intimal thickening formation. Histology and Histopathology, 2007;22(12):1379-1386). Additional information can be obtained by contacting L. Diazflores, La Laguna University, Faculty Medical, Dept. of Patol, Tenerife, Spain. The publisher of the journal Histology and Histopathology can be contacted at: F Hernandez, Plaza Fuensanta 2-7 C, 30008 Murcia, Spain. Keywords: Spain, Progenitor Cell, Stem Cell Research, La Laguna University, Medical Department. This article was prepared by Stem Cell Week editors from staff and other reports. Copyright 2007, Stem Cell Week via NewsRx.com.
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