Study results from N. Espinolazavaleta et al provide new insights into takayasu arteritis
2009 MAY 18 - (NewsRx.com) -- According to a study from Mexico, "Takayasu's arteritis (TA) is an idiopathic chronic inflammatory disease that causes occlusion of large arteries, but little is known about whether affected patients are characterized by endothelial dysfunction, different high-density lipoproteins (HDL) subclasses and paraoxonase-1 (PON1) activity. In the present study, 30 patients with TA, 30 age- and gender-matched volunteers (controls) and 15 patients with essential hypertension were studied, Flow-mediated vasodilation (FMD) and maximal blood flow velocity, assessed in the brachial artery by high-resolution ultrasound, were significantly lower in patients." "HDL subclass distribution was determined by polyacrylamide gradient gel electrophoresis. HDL-cholesterol, HDL3b subclass and PON1 activity, assessed spectrophotometrically using phenylacetate as the substrate, were also lower in patients compared with controls. In a multiple regression analysis, the use of prednisone and systolic blood pressure were independent variables that predicted the FMD. A low FMD, abnormal size distribution of HDLs, and low PON1 activity are observed in TA patients," wrote N. Espinolazavaleta and colleagues. The researchers concluded: "These abnormalities appear independently and constitute a cluster that may contribute to the vascular dysfunction of TA arteritis. (Circ J 2009;73:760-766)'." Espinolazavaleta and colleagues published their study in Circulation Journal (Altered Flow-Mediated Vasodilatation, Low Paraoxonase-1 Activity, and Abnormal High-Density Lipoprotein Subclass Distribution in Takayasu's Arteritis. Circulation Journal, 2009;73(4):760-766). For more information, contact N. Espinolazavaleta, Institute Nacl Cardiology Ignacio Chavez, Dept. of Molecular Biology, Juan Badiano 1, Secc 16, Mexico City 14080, DF, Mexico. Publisher contact information for the Circulation Journal is: Japanese Circulation Society, Kinki Invention Center, 14 Yoshida Kawaharacho, Sakyo-Ku, Kyoto, 606-8305, Japan. Keywords: Mexico, Angiology, Brachial Artery, Cardiology, Circulation, Essential Hypertension, Gender Health, Gender Medicine, Hypertension, Nephrology, Takayasu Arteritis, Vasculitis, Women's Health. This article was prepared by Hematology Week editors from staff and other reports. Copyright 2009, Hematology Week via NewsRx.com.
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