Researchers from Medical College of Wisconsin detail new studies and findings in the area of corneal edema therapy
2009 JUL 20 - (NewsRx.com) -- A new study, 'Nonimmunologic graft failure after Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) for presumed amantadine-induced corneal edema,' is now available. "With one exception, a case report of amantadine-induced corneal toxicity has described reversible corneal edema. To report a patient with unrecognized amantadine-induced corneal edema," scientists writing in the journal Eye and Contact Lens report. "Patient with schizophrenia and tardive dyskinesia developed bilateral corneal edema while receiving chronic amantadine hydrochloride. Both eyes underwent successful phakic Descemet's stripping automated endothelial keratoplasty, and histopathologic examination of the excised host tissue was performed. Despite initial clearing of the donor lenticules, both eyes later experienced nonimmunologic graft failure, probably related to continued amantadine corneal toxicity. After discontinuation of the amantadine, one graft demonstrated partial clearing. Histopathology demonstrated endothelial cell loss. Specular microscopy demonstrated pleomorphism and disruption of the orderly hexagonal array," wrote S.B. Koenig and colleagues, Medical College of Wisconsin. The researchers concluded: "Chronic amantadine hydrochloride therapy may be responsible for irreversible corneal edema and may lead to graft failure in unrecognized cases." Koenig and colleagues published their study in Eye and Contact Lens (Nonimmunologic graft failure after Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) for presumed amantadine-induced corneal edema. Eye and Contact Lens, 2009;35(4):209-11). Additional information can be obtained by contacting S.B. Koenig, Eye Institute, Froedtert and Medical College of Wisconsin, Milwaukee, 53226 USA.. The publisher of the journal Eye and Contact Lens can be contacted at: Nature Publishing Group, 345 Park Avenue South, New York, NY 10010-1707, USA. Keywords: United States, Milwaukee, Corneal Edema Therapy, Amantadine Hydrochloride, Analgesic, Antiparkinson, Antiviral, Contact Lens, Corneal Edema, Dopamine Agent, Drugs, Medical Device, Neurology, Pharmaceuticals, Psychiatry, Schizophrenia, Tardive Dyskinesia, Therapy, Treatment. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
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