Reports outline clinical trial research research from J.A. Paoloni and colleagues
2009 JUN 8 - (NewsRx.com) -- "This study aimed to determine whether a new glyceryl trinitrate patch preparation is effective in treating chronic lateral epicondylosis. Randomised double-blind controlled clinical trial," investigators in Kogarah, Australia report. "Private practice patients: 154 adult patients with chronic lateral epicondylosis were recruited, with 136 patients completing the trial. 8 weeks of glyceryl trinitrate patch application (dosages of 72 mg/24 h, 1.44 mg/24 h, and 3.6 mg/24 h), or placebo patch application. Subjective global assessment of change in elbow symptoms, patient-rated tennis elbow evaluation, visual analogue pain at rest, visual analogue pain with activity, visual analogue pain intensity, grip strength, and strength testing using the Orthopaedic Research Institute-Tennis Elbow Testing System. At 8 weeks there was a significant decrease in elbow pain with activity in the glyceryl trinitrate 0.72 mg/24 h group compared with placebo (p=0.04). There were no other significant differences. Continuous 1.25 mg/24 h topical glyceryl trinitrate treatment, when combined with daily exercise rehabilitation, has previously demonstrated efficacy in treating chronic lateral epicondylosis. There was significantly decreased elbow pain with activity at 8 weeks in the glyceryl trinitrate 0.72 mg/24 h group (p=0.04)," wrote J.A. Paoloni and colleagues. The researchers concluded: "This short-term dose-ranging study did not demonstrate a treatment effect of a new topical glyceryl trinitrate patch in dosages of 1.44 mg/24 h or 3.6 mg/24 h, which conflicts with previous studies on topical glyceryl trinitrate treatment." Paoloni and colleagues published their study in British Journal of Sports Medicine (Randomised, double-blind, placebo-controlled clinical trial of a new topical glyceryl trinitrate patch for chronic lateral epicondylosis. British Journal of Sports Medicine, 2009;43(4):299-302). For additional information, contact J.A. Paoloni, Orthopedic Research Institute, 2nd Floor, 4 South St., Kogarah, NSW 2217, Australia. The publisher of the British Journal of Sports Medicine can be contacted at: B M J Publishing Group, British Med Association House, Tavistock Square, London WC1H 9JR, England. Keywords: Australia, Kogarah, Clinical Trial Research, Orthopedics, Tennis Elbow. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
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