Teratocarcinoma
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Research from University of California provides new data on teratocarcinoma
2009 MAY 11 - (NewsRx.com) -- "In a Perspectives article of 1985 in Cancer Research, I discussed evidence for a nonmutational origin of teratocarcinoma, and cited related claims in liver carcinogenesis, which I later broadened to include spontaneous transformation in cell culture. Further research on spontaneous transformation cast doubt on that interpretation, and motivated re-examination of the cases for teratocarcinomas and liver cancer," researchers in the United States report. "This re-examination led to the conclusion that mutation and selection underlie the development of neoplasia in all three cases. At the same time, it affirmed the primary role of hierarchical tissue structure and intercellular relations in maintaining homeostasis, which was the major theme of the 1985 article," wrote H. Rubin and colleagues, University of California. The researchers concluded: "Tumor promotion disrupts intercellular relations to allow progressively selective proliferation of initiated cells and accompanying clonal accumulation of genetic change. [Cancer Res 2009;69(6):2171-5]'." Rubin and colleagues published their study in Cancer Research (Rethinking ''Cancer as a Dynamic Developmental Disorder'' a Quarter Century Later. Cancer Research, 2009;69(6):2171-2175). For additional information, contact H. Rubin, University of California, Dept. of Molecular & Cell Biology, 229 Stanley Hall, Berkeley, CA 94720, USA. Publisher contact information for the journal Cancer Research is: American Association Cancer Research, 615 Chestnut St., 17TH Floor, Philadelphia, PA 19106-4404, USA. Keywords: United States, Berkeley, Cancer Research, Carcinogenesis, Liver Cancer, Liver Carcinoma, Oncology, Teratocarcinoma, University of California. This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2009, Clinical Oncology Week via NewsRx.com.
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