Reports outline teratocarcinoma research from U. Silván and colleagues
2009 JUL 13 - (NewsRx.com) -- Investigators publish new data in the report 'Angiogenesis and vascular network of teratocarcinoma from embryonic stem cell transplant into seminiferous tubules.' "Carcinoma in situ (CIS) of the testis is considered to be a precancerous germinal cell lesion, but the precise cellular and molecular mechanisms underlying transformation of CIS into invasive pluripotent cancer cells remain to be elucidated. Moreover, a satisfactory animal model for the experimental study of germinal tumours has not been developed to date," researchers in Spain report. "We have developed a tumor model that involves the microinjection of green fluorescent protein-labelled embryonic stem (ES) cells (which are functionally equivalent to CIS cells) into syngenic mouse seminiferous tubules, a unique cell microenvironment in which germinal cells mature and CIS arise. To characterise the vascularisation of teratocarcinomas, which arise after cell transplant, we used immunohistochemistry, together with a qualitative and quantitative analysis of scanning electron microscopy images of corrosion casting samples. Embryonic stem cells transplanted into seminiferous tubules did not differentiate into germinal cells, but rather they behaved as invasive embryonal carcinoma (EC) stem cells. The vascular pattern of the experimental teratocarcinomas showed a highly disorganised architecture, and some of the neoplastic capillaries were derived, at least in part, from the original transplanted ES cells. The transplantation of pluripotent ES cells into seminiferous tubules efficiently recapitulates the early stages of development of teratocarcinomas," wrote U. Silván and colleagues, . The researchers concluded: "Consequently, this method constitutes a novel in vivo model to study the mechanisms of invasion and progression of experimental germinal tumours." Silván and colleagues published their study in British Journal of Cancer (Angiogenesis and vascular network of teratocarcinoma from embryonic stem cell transplant into seminiferous tubules. British Journal of Cancer, 2009;101(1):64-70). For additional information, contact U. Silván, Laboratory of Stem Cells, Dept. of Cell Biology and Histology, Development and Cancer, Leioa, Vizcaya, Spain. Publisher contact information for the British Journal of Cancer is: Nature Publishing Group, 345 Park Avenue South, New York, NY 10010-1707, USA. Keywords: Spain, Angiogenesis, Biotechnology Business, Biotechnology Company, Cancer, Carcinoma in Situ, Embryonic Stem Cell Research, Oncology, ProteinLabs, Teratocarcinoma, Tumor Vascularization. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
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